肠道菌群与阿尔茨海默病的研究进展

doi:10.3969/j.issn.1004-583X.2021.02.016

摘要/Abstract

摘要：

近年来发现肠道菌群与阿尔茨海默症(Alzheimer’s disease, AD)有着密切联系。肠道菌群通过微生物-肠-脑轴调节神经元的发育,而肠道菌群紊乱则导致神经系统疾病,如AD。肠道菌群失调引起的中枢神经功能紊乱、慢性炎症、β-样淀粉蛋白(amyloid β-protein, Aβ)沉积、递质失衡和氧化应激等都会加重AD进展。益生元、益生菌、中医药、粪菌移植、抗生素和特定饮食方式可能是AD防治和治疗的潜在靶点,幽门螺杆菌感染、慢性噪声和铝是AD的潜在危险。

关键词: 阿尔茨海默病, 肠杆菌科, 代谢, 微生物学

中图分类号:

R593.24

马光宇, 宋崇东, 韩语纯, 张荣福, 张哲, 程爽, 苏亚楠. 肠道菌群与阿尔茨海默病的研究进展[J]. 临床荟萃, 2021, 36(2): 174-178.

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https://huicui.hebmu.edu.cn/CN/Y2021/V36/I2/174

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肠道菌群与阿尔茨海默病的研究进展

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