临床荟萃 ›› 2021, Vol. 36 ›› Issue (1): 89-92.doi: 10.3969/j.issn.1004-583X.2021.01.019
武媚曼1, 华毛2(
)
收稿日期:2020-06-26
出版日期:2021-01-20
发布日期:2021-01-16
通讯作者:
华毛
E-mail:13997239041@163.com
基金资助:
Received:2020-06-26
Online:2021-01-20
Published:2021-01-16
摘要：
慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)目前是全世界范围内发病率和死亡率最高的疾病之一,是严重的公共卫生问题。肺动脉高压是COPD常见的并发症。目前关于肺动脉高压的发病机制尚不明确,缺氧在COPD合并肺动脉高压的发病中扮演着重要的角色,而高原地区环境的低氧会加重呼吸系统疾病。有研究发现在肺动脉高压的发生、发展过程中,导致凝血功能改变的众多因素中,炎症因子可能占主导性作用,本文主要探讨肿瘤坏死因子α(TNF-α)、组织因子在肺动脉高压中的发病机制中与凝血功能之间的作用,为高原地区肺动脉高压的发生发展提供新的理论依据。
中图分类号:
武媚曼, 华毛. 高原慢性阻塞性肺疾病合并肺动脉高压TNF-α、组织因子与凝血功能的研究进展[J]. 临床荟萃, 2021, 36(1): 89-92.
| [1] | 中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 慢性阻塞性肺疾病基层诊疗指南[J]. 中华全科医师杂志, 2018,17(11):856-870. |
| [2] |
Hurdman J, Condliffe R, Elliot CA, et al. Pulmonary hypertension in COPD: results from the ASPIRE registry[J]. Eur Respir J, 2013,41(6):1292-1301.
doi: 10.1183/09031936.00079512 URL |
| [3] |
Gao Y, Chen T, Raj JU. Endothelial and smooth muscle cell interactions in the pathobiology of pulmonary hypertension[J]. Am J Respir Cell Mol Biol, 2016,54(4):451-460.
doi: 10.1165/rcmb.2015-0323TR URL |
| [4] |
Sun DL, Li SM, Cen YY, et al. Accuracy of using serum D-dimer for diagnosis of acute intestinal ischemia: A meta-analysis[J]. Medicine (Baltimore), 2017,96(13):e6380.
doi: 10.1097/MD.0000000000006380 URL |
| [5] |
Bourbeau J, Sebaldt RJ, Day A, et al. Practice patterns in the management of chronic obstructive pulmonary disease in primary practice: the CAGE study[J]. Can Respir J, 2008,15(1):13-19.
pmid: 18292848 |
| [6] | 王静, 万钧, 王辰, 等. 慢性肺部疾病所致肺动脉高压靶向药物治疗研究进展[J]. 中国实用内科杂志, 2019,39(2):174-178. |
| [7] |
Mekov E, Slavova Y, Tsakova A, et al. Metabolic syndrome in hospitalized patients with chronic obstructive pulmonary disease[J]. Peer J, 2015,3:e1068.
doi: 10.7717/peerj.1068 URL |
| [8] | 杨生岳, 戴胜归. 高原地区慢性肺心病诊断与治疗中值得注意的几个特殊问题[J]. 中华肺部疾病杂志(电子版), 2014,7(3):243-246. |
| [9] |
Hernandez P, Balter MS, Bourbeau J, et al. Canadian practice assessment in chronic obstructive pulmonary disease: respiratory specialist physician perception versus patient reality[J]. Can Respir J, 2013,20(2):97-105.
doi: 10.1155/2013/369019 URL |
| [10] |
Cracowski JL, Chabot F, Labarère J, et al. Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension[J]. Eur Respir J, 2014,43(3):915-917.
doi: 10.1183/09031936.00151313 URL |
| [11] |
Kim HJ, Yoo HY. Hypoxic pulmonary vasoconstriction and vascular contractility in monocrotaline-induced pulmonary arterial hypertensive rats[J]. Korean J Physiol Pharmacol, 2016,20(6):641-647.
doi: 10.4196/kjpp.2016.20.6.641 URL |
| [12] | 舒微, 梁民勇, 向明钧. 慢性阻塞性肺疾病并发肺动脉高压的研究进展[J]. 中国当代医药. 2019,26(25):32-35. |
| [13] | Shimoda LA, Yun X, Sikka G. Revisiting the role of hypoxia-inducible factors in pulmonary hypertension[J]. Curr Opin Physiol, 2019,7:33-40. |
| [14] |
Xiong PY, Potus F, Chan W, et al. Models and molecular mechanisms of world health organization group 2 to 4 pulmonary hypertension[J]. Hypertension, 2018,71(1):34-55.
doi: 10.1161/HYPERTENSIONAHA.117.08824 pmid: 29158355 |
| [15] |
Kojima H, Tokunou T, Takahara Y, et al. Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension[J]. Physiol Rep, 2019,7(7):e14025.
doi: 10.14814/phy2.14025 URL |
| [16] |
Ricard N, Tu L, Le Hiress M, et al. Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension[J]. Circulation, 2014,129(15):1586-1597.
doi: 10.1161/CIRCULATIONAHA.113.007469 URL |
| [17] |
Itoh A, Nishihira J, Makita H, et al. Effects of IL-1beta, TNF-alpha, and macrophage migration inhibitory factor on prostacyclin synjournal in rat pulmonary artery smooth muscle cells[J]. Respirology, 2003,8(4):467-472.
doi: 10.1046/j.1440-1843.2003.00491.x URL |
| [18] |
Sutendra G, Dromparis P, Bonnet S, et al. Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension[J]. J Mol Med (Berl), 2011,89(8):771-783.
doi: 10.1007/s00109-011-0762-2 URL |
| [19] |
Chen YW, Leung JM, Sin DD. A Systematic Review of Diagnostic Biomarkers of COPD Exacerbation[J]. PLoS One, 2016,11(7):e0158843.
doi: 10.1371/journal.pone.0158843 URL |
| [20] | 黄茉莉, 梅晓冬, 王卫阳. 慢性阻塞性肺疾病患者血清炎症因子水平及其临床意义[J]. 中国老年学杂志, 2019,39(24):5973-5976. |
| [21] |
Chauhan AK, Kisucka J, Lamb CB, et al. von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins[J]. Blood, 2007,109(6):2424-2429.
pmid: 17119108 |
| [22] |
Oszajca K, Wroński K, Janiszewska G, et al. The study of t-PA, u-PA and PAI-1 genes polymorphisms in patients with abdominal aortic aneurysm[J]. Mol Biol Rep, 2014,41(5):2859-2864.
doi: 10.1007/s11033-014-3141-6 URL |
| [23] | 何新文. 浅论肺癌与肺癌合并肺部感染患者血常规指标、血清炎性因子及凝血指标的差异性[J]. 当代医药论丛, 2017,5(10):8-9. |
| [24] | 刘领, 吴文杰, 杨霁, 等. 慢性阻塞性肺疾病患者炎症反应与凝血功能异常的关系[J]. 中国医刊, 2015,50(8):47-50. |
| [25] | 李志伟, 王著军, 徐旭, 等. TNF-α、LPS、IL-6、PAT与颅脑损伤后急性凝血功能障碍的相关性[J]. 中国临床神经外科杂志, 2015,20(1):25-27. |
| [26] |
Aziz M, Jacob A, Wang P. Revisiting caspases in sepsis[J]. Cell Death Dis, 2014,5(11):e1526.
doi: 10.1038/cddis.2014.488 URL |
| [27] |
Okamoto K, Tamura T, Sawatsubashi Y. Sepsis and disseminated intravascular coagulation[J]. J Intensive Care, 2016,4:23.
doi: 10.1186/s40560-016-0149-0 pmid: 27011792 |
| [28] | 戴艳枝, 王晓华, 刘秋玲, 等. 白细胞介素-1β、白细胞介素-8及肿瘤坏死因子-α与房颤伴凝血功能异常的相关性[J]. 中国当代医药, 2019,26(23):4-7. |
| [29] | 李少昆, 安生花, 郭凤龙, 等. 肺癌患者血清TNF-α、IL-6与凝血功能的相关性研究[J]. 实用癌症杂志. 2018,33(11):1773-1776. |
| [30] |
Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis[J]. Arterioscler Thromb Vasc Biol, 2007,27(8):1687-1693.
doi: 10.1161/ATVBAHA.107.141911 URL |
| [31] |
Konoeda H, Yamaki T, Hamahata A, et al. Incidence of deep vein thrombosis in patients undergoing breast reconstruction with autologous tissue transfer[J]. Phlebology, 2017,32(4):282-288.
doi: 10.1177/0268355516680427 pmid: 27864561 |
| [32] |
Cote DJ, Smith TR. Venous thromboembolism in brain tumor patients[J]. J Clin Neurosci, 2016,25:13-18.
doi: 10.1016/j.jocn.2015.05.053 URL |
| [33] |
Witkowski M, Landmesser U, Rauch U. Tissue factor as a link between inflammation and coagulation[J]. Trends Cardiovasc Med, 2016,26(4):297-303.
doi: 10.1016/j.tcm.2015.12.001 URL |
| [34] |
Rehani T, Mathson K, Belcher JD, et al. Heme potently stimulates tissue factor expression by peripheral blood monocytes: a novel mechanism for thrombosis in intravascular hemolytic diseases[J]. Blood, 2013,122(21):2215.
doi: 10.1182/blood.V122.21.2215.2215 URL |
| [35] |
Mitroulis I, Kambas K, Anyfanti P, et aI. The multivalent activity of the tissue factor-thrombin pathway in thrombotic and non-thrombotic disorders as a target for therapeutic intervention[J]. Expert Opin Ther Targets, 2011,15(1):75-89.
doi: 10.1517/14728222.2011.532788 URL |
| [36] |
Butenas S, Bouchard BA, Brummel-Ziedins KE, et al. Tissue factor activity in whole blood[J]. Blood, 2005,105(7):2764-2770.
doi: 10.1182/blood-2004-09-3567 URL |
| [37] |
Maugeri N, Manfredi AA. Tissue factor expressed by neutrophils: another piece in the vascular inflammation puzzle[J]. Semin Thromb Hemost, 2015,41(7):728-736.
doi: 10.1055/s-00000077 URL |
| [38] | 赵晟, 姚小燕, 薛新颖, 等. 低压低氧性肺动脉高压中组织因子致高凝状态的研究[J]. 中国分子心脏病学杂志, 2016,16(6):1920-1922. |
| [39] |
Andreasen EB, Nielsen OL, Tranholm M, et al. Expression of tissue factor in canine mammary tumours and correlation with grade, stage and markers of haemostasis and inflammation[J]. Vet Comp Oncol, 2016,14(2):191-201.
doi: 10.1111/vco.12089 pmid: 24674618 |
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