肠道微生物菌群对阿尔兹海默症的相关作用机制

doi:10.3969/j.issn.1004-583X.2021.01.018

摘要/Abstract

摘要：

通过整理当前的关键发现并对当前研究中面临的问题进行归纳。叙述了肠道菌群对阿尔兹海默症(Alzheimer's disease,AD)发病机制及影响。实验研究结果发现,微生物细菌分泌物对AD发病产生相关影响,如脆弱拟杆菌释放的脂多糖(BF-LPS),暴露于人体中枢神经系统后,促进AD病程的进一步发展,对机体免疫反应和认知功能产生显著改变。其次通过益生菌治疗影响人体肠道微生态平衡以及饮食方面的自主改变等外界干预,对逆转AD病程具有重要作用。

关键词: 阿尔茨海默病, 肠杆菌科, 淀粉样蛋白, 肠毒素类

中图分类号:

R542

张立愔, 许龙, 吕冬云, 孙睿, 张国超, 盛雪. 肠道微生物菌群对阿尔兹海默症的相关作用机制[J]. 临床荟萃, 2021, 36(1): 84-88.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.01.018

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I1/84

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参考文献 39

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肠道微生物菌群对阿尔兹海默症的相关作用机制

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