尤瑞克林联合阿替普酶溶栓治疗急性脑梗死的疗效及对神经功能与炎症因子的影响

doi:10.3969/j.issn.1004-583X.2021.06.005

摘要/Abstract

摘要：

目的探讨尤瑞克林联合阿替普酶溶栓治疗急性脑梗死的临床疗效及对患者神经功能、炎性因子水平、生活质量的影响。方法回顾性分析本院收治的急性脑梗死患者90例,按照治疗方案分成两组,对照组45例,采用常规治疗+尤瑞克林治疗;观察组45例,在对照组基础上联合阿替普酶溶栓治疗。比较两组临床疗效、神经功能恢复程度、炎性因子变化及生活质量水平。结果观察组治疗总有效率高于对照组(93.33% vs 73.33%,P<0.05)。观察组NIHSS、CSS评分低于对照组,BI评分高于对照组(P<0.05)。观察组CRP、PCT、IL-8水平低于对照组(P<0.05)。观察组WHOQOL-BREF评分高于对照组(P<0.05)。结论常规治疗的基础上以尤瑞克林联合阿替普酶溶栓治疗急性脑梗死的应用效果理想,可促进神经功能、运动功能恢复,并且可缓解炎性反应,使患者生活质量得到改善。

关键词: 尤瑞克林, 脑梗死, 阿替普酶, 溶栓治疗, 神经功能

Abstract:

Objective To investigate the clinical effect of Urinary Kallidinogenase combined with Alteplase thrombolysis for acute cerebral infarction and its influence on nerve function, inflammatory factors and the quality of life. Methods In the study, 90 patients with acute cerebral infarction admitted to our hospital were retrospectively analyzed, all the patients were divided into two groups according to the difference of treatment plan, the control group (n=45) was treated with routine treatment puls Urinary Kallidinogenase, the observation group (n=45) were additionally treated Alteplase thrombolytic therapy on the basis of the control group. The clinical efficacy, nerve function recovery, inflammatory factors, as well as the quality of life were compared between the two groups. Results The total effective rate in the observation group was higher than that in the control group (93.33% vs 73.33%, P<0.05). NIHSS, CSS score in observation group was lower than those in control group, while BI score was higher than that in control group (P<0.05). The levels of CRP、PCT、IL-8 in the observation group was lower than those in control group after treatment (P<0.05). The WHOQOL-BREF score in observation group was higher than that in control group(P<0.05). Conclusion For acute cerebral infarction, the additional application of Ureicline kallidinogenase combined with Alteplase thrombolysis in the treatment on the basis of conventional treatment has ideal effect, which can promote the recovery of nerve function and motor function, relieve the inflammatory response, and improve the quality of life of patients.

Key words: urinary kallidinogenase, brain infarction, alteplase, thrombolytic therapy, nerve function

中图分类号:

R743.33

刘仲秋, 初建峰. 尤瑞克林联合阿替普酶溶栓治疗急性脑梗死的疗效及对神经功能与炎症因子的影响[J]. 临床荟萃, 2021, 36(6): 509-512.

Liu Zhongqiu, Chu Jianfeng. Efficacy of Ureklin combined with Alteplase for acute cerebral infarction and its influence on nerve function and inflammatory factors[J]. Clinical Focus, 2021, 36(6): 509-512.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.06.005

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I6/509

图/表 4

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组别	例数	显效	有效	无效	总有效率
观察组	45	20(44.44)	22(48.89)	3(6.67)	42(93.33)
对照组	45	15(33.33)	18(40.00)	12(26.67)	33(73.33)
χ²值					6.480
P值					0.011

组别	例数	显效	有效	无效	总有效率
观察组	45	20(44.44)	22(48.89)	3(6.67)	42(93.33)
对照组	45	15(33.33)	18(40.00)	12(26.67)	33(73.33)
χ²值					6.480
P值					0.011

组别	例数	NIHSS		BI		CSS
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	45	10.12±2.62	4.52±1.52^*	27.41±8.22	70.21±6.52^*	35.11±6.92	24.11±4.52^*
对照组	45	10.25±2.70	6.16±1.69^*	27.45±8.32	60.59±7.11^*	35.52±6.78	28.62±4.83^*
t值		0.232	4.840	0.023	6.690	0.284	4.574
P值		0.817	<0.01	0.982	<0.01	0.777	<0.01

组别	例数	NIHSS		BI		CSS
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	45	10.12±2.62	4.52±1.52^*	27.41±8.22	70.21±6.52^*	35.11±6.92	24.11±4.52^*
对照组	45	10.25±2.70	6.16±1.69^*	27.45±8.32	60.59±7.11^*	35.52±6.78	28.62±4.83^*
t值		0.232	4.840	0.023	6.690	0.284	4.574
P值		0.817	<0.01	0.982	<0.01	0.777	<0.01

组别	例数	CRP(mg/L)		PCT(ng/ml)		IL-8(ng/L)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	45	28.54±4.52	7.62±1.52^*	2.56±0.52	0.67±0.12^*	45.51±9.52	24.67±6.42^*
对照组	45	27.95±4.55	11.02±1.69^*	2.66±0.56	0.80±0.15^*	45.66±9.41	33.45±7.22^*
t值		0.617	10.034	0.878	5.139	0.075	6.096
P值		0.539	<0.01	0.382	<0.01	0.940	<0.01