临床荟萃 ›› 2022, Vol. 37 ›› Issue (8): 743-747.doi: 10.3969/j.issn.1004-583X.2022.08.013
周彦伶1, 朱斌斌2(
), 曹盎洋1, 罗文君1
收稿日期:2022-02-17
出版日期:2022-08-20
发布日期:2022-09-26
通讯作者:
朱斌斌
E-mail:pingchi1983@126.com
基金资助:
Received:2022-02-17
Online:2022-08-20
Published:2022-09-26
摘要：
神经认知障碍是以认知功能水平下降为特征的一类疾病,严重影响患者生活的自主性和独立性。由于药物治疗的副作用及疗效的不确定性,人们对非药物治疗的需求越来越迫切。研究表明,虚拟现实技术对神经认知障碍有改善作用。本文通过对虚拟现实技术在神经认知障碍中的应用及相关机制进行综述,旨在为临床神经认知障碍的非药物干预提供依据。
中图分类号:
周彦伶, 朱斌斌, 曹盎洋, 罗文君. 虚拟现实技术改善神经认知障碍的研究进展[J]. 临床荟萃, 2022, 37(8): 743-747.
| 作者 | 病种 | 评估工具 | VR干预 | 改善方面 | 可能机制 | |||
|---|---|---|---|---|---|---|---|---|
| 干预 方式 | 沉浸 程度 | 时间 | 干预频率 | |||||
| Anderson-Hanley 2012[ | 正常老年人 | MMSE、Stroop C | 游戏 | 半沉浸式 | 8周 | 5次/周,45 min/次 | 认知功能、自理能力 | BDNF增加 |
| Liao 2020[ | MCI | TMT、SCWT、步态性能评估 | 任务 | 沉浸式 | 12周 | 3次/周,60 min/次 | 知觉-运动功能、执行功能、注意力、自理能力 | 认知刺激 |
| Torpil 2021[ | MCI | LOTCA-G | 游戏 | 沉浸式 | 12周 | 2次/周,45 min/次 | 知觉-运动功能、认知功能、注意力 | 认知刺激 |
| Liao 2019[ | MCI | Moca、IADL | 任务 | 沉浸式 | 12周 | 3次/周,60 min/次 | 执行功能、注意力、语言能力 | 神经可塑性 |
| Riaz 2021[ | MCI | Moca | 游戏 | 沉浸式 | 6周 | 2次/周,40 min/次 | 认知功能、心理功能 | 环境刺激 |
| Bahar-Fuchs 2019[ | 正常老年人、痴呆症 | MMSE、ACE-III | 游戏 | 沉浸式 | 6周 | 2次/周,45~60 min/次 | 知觉-运动功能、学习和记忆能力 | 认知刺激 |
| Oliveira 2021[ | AD | MMSE、IADL | 任务 | 非沉浸式 | 2周 | 2次/周,45 min/次 | 认知功能 | 认知储备 |
| Serino 2017[ | AD | MMSE、Fab | 任务 | 半沉浸式 | 3~ 4周 | 3次/周,10~15 min/次 | 知觉-运动功能、执行功能 | 认知刺激;增强额叶和海马体功能;神经可塑性 |
| Doniger 2018[ | AD | MRI | 任务 | 沉浸式 | 12周 | 2次/周,45 min/次 | 认知功能、执行功能、学习和记忆能力 | 认知储备;神经可塑性;激活前额叶和海马体 |
| White 2016[ | AD | Moca、MMSE | 任务 | 沉浸式 | 7周 | 3次/周,45 min/次 | 认知功能、学习和记忆能力、自理能力、幸福感 | 认知储备;激活海马体;BDNF增加 |
| Panerai 2021[ | AD | MMSE、IADL | 任务 | 非沉浸式 | 8周 | 5次/周 60 min/次 | 自理能力 | 认知刺激 |
| Bauer 2020[ | 正常老年人 | Moca | 任务 | 沉浸式 | 6周 | 2次/周,30 min/次 | 认知功能、执行功能、注意力、幸福感 | 认知刺激 |
| Delbroek 2017[ | 正常老年人 | Moca、IMI | 任务 | 非沉浸式 | 6周 | 12次/周,30 min/次 | 注意力、记忆力、 平衡力 | 未提 |
| Maeng 2021[ | MCI | 数字广度试验、Stroop-C | 任务 | 沉浸式 | 4周 | 2次/周,50 min/次 | 学习和记忆,额叶功能方面的认知改善 | 额叶激活,认知 刺激 |
| Hwang 2017[ | MCI | MMSE、视觉广度测试 | 任务 | 半沉浸式 | 4周 | 5次/周,30 min/次 | 缓解抑郁,改善认知和平衡能力 | 未提 |
表1 VR干预方式及其疗效评价
| 作者 | 病种 | 评估工具 | VR干预 | 改善方面 | 可能机制 | |||
|---|---|---|---|---|---|---|---|---|
| 干预 方式 | 沉浸 程度 | 时间 | 干预频率 | |||||
| Anderson-Hanley 2012[ | 正常老年人 | MMSE、Stroop C | 游戏 | 半沉浸式 | 8周 | 5次/周,45 min/次 | 认知功能、自理能力 | BDNF增加 |
| Liao 2020[ | MCI | TMT、SCWT、步态性能评估 | 任务 | 沉浸式 | 12周 | 3次/周,60 min/次 | 知觉-运动功能、执行功能、注意力、自理能力 | 认知刺激 |
| Torpil 2021[ | MCI | LOTCA-G | 游戏 | 沉浸式 | 12周 | 2次/周,45 min/次 | 知觉-运动功能、认知功能、注意力 | 认知刺激 |
| Liao 2019[ | MCI | Moca、IADL | 任务 | 沉浸式 | 12周 | 3次/周,60 min/次 | 执行功能、注意力、语言能力 | 神经可塑性 |
| Riaz 2021[ | MCI | Moca | 游戏 | 沉浸式 | 6周 | 2次/周,40 min/次 | 认知功能、心理功能 | 环境刺激 |
| Bahar-Fuchs 2019[ | 正常老年人、痴呆症 | MMSE、ACE-III | 游戏 | 沉浸式 | 6周 | 2次/周,45~60 min/次 | 知觉-运动功能、学习和记忆能力 | 认知刺激 |
| Oliveira 2021[ | AD | MMSE、IADL | 任务 | 非沉浸式 | 2周 | 2次/周,45 min/次 | 认知功能 | 认知储备 |
| Serino 2017[ | AD | MMSE、Fab | 任务 | 半沉浸式 | 3~ 4周 | 3次/周,10~15 min/次 | 知觉-运动功能、执行功能 | 认知刺激;增强额叶和海马体功能;神经可塑性 |
| Doniger 2018[ | AD | MRI | 任务 | 沉浸式 | 12周 | 2次/周,45 min/次 | 认知功能、执行功能、学习和记忆能力 | 认知储备;神经可塑性;激活前额叶和海马体 |
| White 2016[ | AD | Moca、MMSE | 任务 | 沉浸式 | 7周 | 3次/周,45 min/次 | 认知功能、学习和记忆能力、自理能力、幸福感 | 认知储备;激活海马体;BDNF增加 |
| Panerai 2021[ | AD | MMSE、IADL | 任务 | 非沉浸式 | 8周 | 5次/周 60 min/次 | 自理能力 | 认知刺激 |
| Bauer 2020[ | 正常老年人 | Moca | 任务 | 沉浸式 | 6周 | 2次/周,30 min/次 | 认知功能、执行功能、注意力、幸福感 | 认知刺激 |
| Delbroek 2017[ | 正常老年人 | Moca、IMI | 任务 | 非沉浸式 | 6周 | 12次/周,30 min/次 | 注意力、记忆力、 平衡力 | 未提 |
| Maeng 2021[ | MCI | 数字广度试验、Stroop-C | 任务 | 沉浸式 | 4周 | 2次/周,50 min/次 | 学习和记忆,额叶功能方面的认知改善 | 额叶激活,认知 刺激 |
| Hwang 2017[ | MCI | MMSE、视觉广度测试 | 任务 | 半沉浸式 | 4周 | 5次/周,30 min/次 | 缓解抑郁,改善认知和平衡能力 | 未提 |
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