Effects of levothyroxine sodium on perinatal outcome women during early trimester of pregnancy with subclinical hypothyroidism and TPoAb-negative

doi:10.3969/j.issn.1004-583X.2016.03.015

Abstract

Abstract: Objective To investigate the effects of levothyroxine sodium on perinatal outcome women during early trimester of pregnancy with subclinical hypothyroidism and TPoAb-negative.Methods One thousand one hundred and forty patients during early trimester of pregnancy with subclinical hypothyroidism and TPoAb-negative were enrolled. All the patients were divided into control group (n=570) and levothyroxine sodium group (n=570) randomly. Patients in levothyroxine sodium group were given levothyroxine sodium treatment,rate of premature delivery, pregnancy induced hypertension, abortion, anaemia and neonatal body mass were observed.Results Rate of premature delivery,pregnancy induced hypertension, abortion and anaemia in control group were higher than those in levothyroxine sodium group (P<0.05).The rate of spontaneous delivery, hemoglobin and neonatal body mass in control group were lower than those in levothyroxine sodium group (P<0.05). The dosage of L-T4 was positively correlated with the TSH level in levothyroxine sodium group (r=0.763,P<0.05).Conclusion Levothyroxine sodium can improve the pregnancy outcome in the patients during early trimester of pregnancy with subclinical hypothyroidism and TPoAb-negative.

Key words: hypothyroidism, pregnancy, peroxidase, thyroxine

CLC Number:

R581.2

Zhang Jiefang,Li Yuan,Cao Yanmin,Liu Dongli,Ma Min,Xu Hong,Zhao Baojing. Effects of levothyroxine sodium on perinatal outcome women during early trimester of pregnancy with subclinical hypothyroidism and TPoAb-negative[J]. Clinical Focus, 2016, 31(3): 293-295.

Add to citation manager EndNote|Ris|BibTeX

URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.03.015

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I3/293

References

[1] De Vivo A,Mancuso A,Giacobbe A,et al. Thyroid function inwomen found to have early pregnancy loss[J]. Thyroid,2010,20(6):633-637.
[2] Yassa L,Marqusee E,Fawcett R,et al. Thyroid hormone early adjustment in pregnancy (the THERAPY) trial[J].J Clin Endocrinol Metab,2010,95(7): 3234-3241.
[3] 解裕豆,高云.妊娠合并甲状腺功能减退症的研究进展[J].临床误诊误治,2012,25(1):93-96.
[4] 中华医学会内分泌学分会,中华医学会围产医学分会. 妊娠和产后甲状腺疾病诊治指南[J]. 中华内分泌代谢杂志,2012,28(5): 354-371.
[5] Gharib H,Tuttle RM,Baskin HJ,et al. Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical EnSociety[J]. J Clin Endocrinol Metab,2005,90(1): 581-585.
[6] Benhadi N,Wiersinga WM,Reitsma JB,et al. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage,fetal or neonatal death[J]. Eur J Endocrinol,2009,160(6):985-991.
[7] Wang S,Teng WP,Li JX,et al. Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy[J].J Endocrinol Invest,2012,35( 3) : 322-325.
[8] Cleary-Goldman J,Malone FD,Lambert-Meserlian G,et al.Matermal thyriod hypofunction and pergnancy outcome[J].Obstet Gynecol,2008,112(1):85-92.
[9] Negro R,Schwartz A,Gismondi R,et al. Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy[J]. J Clin Endocrinol Metab,2010,95(4): 1699-1707.
[10] Li Y,Shan Z,Teng W,et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30months[J]. Clin Endocrionl(Oxf),2010,72(6):825-829.
[11] Mannisto T, Vaarasmaki M, Pouta A,et al. Thyroid dysfunction and autoantibodies during pergnancy sa predictive factors of pergnancy complications and matermal morbidity in Later Life[J]. J Clin Eendocrinol Metab,2010,95(3):1.84-1094.
[12] Lazarus JH,Bestwick JP,Channon S,et al. Antenatal thyroid screening and childhood cognitive function[J]. N Engl J Med,2012,366( 6) : 493-501.
[13] Patel J, Landers K, Li H, Mortimer RH,et al. Thyroid hormones and fetal neurological development[J]. J Endocrinol,2011,209(1): 1-8.
[14] 高红,佟彤,赵永鲜. 左旋甲状腺素对亚临床甲状腺功能减退症妊娠的影响[J]. 临床药物治疗杂志,2012,10( 6) : 16-19.

[1]	Chi Xiue, Zhang Qian, Li Wendong, Wang Yuansong, Kang Jingrui. Pseudohypoparathyroidism type Ia misdiagnosed as epilepsy: A case report and literatures review [J]. Clinical Focus, 2022, 37(9): 827-830.
[2]	Zuo Xiuxiu, Hou Tianhua, Wang Hongxiang. Effect of subclinical hypothyroidism on prognosis of patients with chronic systolic heart failure: A meta-analysis [J]. Clinical Focus, 2022, 37(10): 905-911.
[3]	Wang Jing, Xu Fangfang, Liu Xiaozhuan. Aortic dissection during pregnancy: A retrospective analysis of 6 patients [J]. Clinical Focus, 2022, 37(1): 52-56.
[4]	Shi Yao, Wang Hu, Chen Min, Li Yuling. Risk factors and pregnancy outcomes of gestational diabetes mellitus in Nanchong area [J]. Clinical Focus, 2021, 36(9): 795-798.
[5]	Cai Kexin, Guo Hongju, Yu Shuxia, Chang Lirong. Effect of levothyroxine for pregnancy outcomes due to subclinical hypothyroidism during pregnancy: A meta-analysis [J]. Clinical Focus, 2021, 36(9): 773-777.
[6]	Zhou Yixuan, Lin Weizhao, Li Ruiman. Relationship between homocysteine and hypertensive disorder complicating pregnancy: a meta-analysis [J]. Clinical Focus, 2021, 36(2): 101-106.
[7]	Zheng Junxia, Ou Jinghua. Predictive value of uKIM-1 and uL-FABP levels on early renal function injury in patients with pregnancy-induced hypertension syndrome [J]. Clinical Focus, 2021, 36(12): 1102-1105.
[8]	You Mu, Cai Manhong. Effect of TPOAb, HbA₁c, PLGF and lipid level on pregnancy outcome in pregnant women with gestational diabetes mellitus [J]. Clinical Focus, 2021, 36(1): 54-57.
[9]	Zhang Yiran. A systematic review of hypoparathyroid cardiomyopathy [J]. Clinical Focus, 2020, 35(9): 783-787.
[10]	Cai Huili. Clinical value of serum sST2, BNP and PAPPA in predicting adverse pregnancy outcomes in pregnancyinduced hypertension patients with heart failure [J]. Clinical Focus, 2020, 35(2): 139-143.
[11]	Wang Liping1, Guo Shaohua1, Wang Chunyan1, Jia Xuqiang2, Sun Liyun2. Low dose gamma globulin in treatment of pregnants with systemic lupus [J]. Clinical Focus, 2019, 34(8): 724-729.
[12]	Du Jianping1，An Zhenmei2a，Tang Xiangdong2b. Influence of obstructive sleep apnea hypopnea syndrome on thyroid function [J]. Clinical Focus, 2018, 33(2): 136-139.
[13]	Zhang Wei1，2， Zhang Mei1， Wang Yucheng1， Cui Dai1， Zhou Hongwen1，. Pseudohypoparathyroidism and hypokalemia: clinical manifestation analysis [J]. Clinical Focus, 2017, 32(9): 759-762.
[14]	Jencia Wong1， Xing Yuwei2， Xu Zhangrong3. Necessity to recognize early gestational diabetes mellitus [J]. Clinical Focus, 2017, 32(8): 661-664.
[15]	Du Ronggui. Association between serum triiodothyronine level and coronary artery disease in elderly patients with low triiodothvronine syndrome [J]. Clinical Focus, 2017, 32(3): 216-219.