Abstract: ObjectiveTo evaluate the efficacy of  tonsillectomy combined with medication therapy (TCMT) on immunoglobulin A nephropathy nephropathy (IgAN). MethodsWe identified eligible studies in either English or Chinese published up to March 31， 2015 by searching Embase， Pubmed， China Biology Medicine disc(CBM)， Chinese National Knowledge Infrastructure(CNKI)，etc. The quality of selected randomized controlled trails or prospective controlled trails that treated IgA nephropathy with TCMT was assessed and metaanalyses were conducted by using Stata statistical software (version 13.0). ResultsSix studies were ultimately enrolled in this metaanalysis， including 3 prospective controlled trails and 3 randomized controlled trails. ①The overall efficacy of TCMT in patients with IgAN: three studies witha total of 224 patients  were included， involving  134  patients in TCMT group and 90 patients in medication therapy group.Pooling results of meta-analysis indicated that TCMT was statistically significantly superior to medication therapy alone (OR=2.68，95%CI=1.474.90，P=0.001). ②The proteinuria remission rate of TCMT in patients with IgAN: 5 studies with a total of 326 patients were included，involving 167 patients in TCMT group and 159 patients in medication therapy group.Meta-analysis showed significant difference between the two groups (OR=4.38，95%CI=2.677.20，P<0.001). ③The remission rate of erythrocyte  of  TCMT with IgAN: five studies with a total of 326 patients  were included，involving 167 patients in TCMT group and 159 patients in medication therapy group. Metaanalysis also indicated that the difference was statistically significant between the two groups (OR=3.90，95%CI=1.3811.07，P=0.01). ConclusionCompared with the single medication therapy， our study indicated that the TCMTcan improve the complete remission of IgAN， proteinuria remission rate and the remission rate of erythrocyte.

Key words: glomerulonephritis, IGA；tonsillectomy, metaanalysis