Abstract: Objective  To explore the association between the large volume fluid resuscitation and hospital mortality risk in severe acute pancreatitis. Methods  Data were collected from hospitalized patients with severe acute pancreatitis from January 1, 2014 to October 31, 2018,including gender, age, height, weight, vital signs at admission, 24hour fluid resuscitation, and treatment outcomes. According to the different amounts of fluid resuscitation, patients were grouped to find the factors influencing the risk of multiple organ failure and death.Results  A total of 231 patients were included in the study, 76 of whom were admitted to the hospital with a 24hour liquid volume of ≥6 000 ml, with an average fluid rehydration volume of (7 628±3 018) ml. There were 155 patients with <6 000 ml, and the average fluid intake was (4 642±2 018) ml. The mortality rates in the two groups were 10.53% and 21.94%, respectively (P<0.05). The proportion of multiple organ failure (respiratory failure, renal failure) was reduced in the highvolume fluid infusion group (P<0.035). The proportion of invasive mechanical ventilation and blood purification was decreased (P<0.05). Conclusion  Large volume fluid resuscitationis associated with decreased mortality and multiple organ failure. Sufficient fluid should be supplied in the early stage in severe pancreatitis.

Key words: pancreatitis, fluid resuscitation, mortality