Abstract: Objective  To investigate the changes of neutrophil gelatinase associated lipocalin(NGAL) and inflammatory cytokines in patients with type 2 diabetes mellituskidney disease (T2DMDKD). Methods  A total of 180 patients with T2DM were selected. According to the excretion rate of urinary microalbumin, they were divided into simple diabetes group, early nephropathy group and clinical nephropathy group. And 60 healthy volunteers were selected as control group.Then the expression levels of NGAL, interleukin 6（IL6）  and tumor necrosis factor α (TNFα)  in each group were detected. Results  Before the treatment, the levels of IL6 and  TNFα in  T2DM patients were significantly higher than those in patients of control group, and the more serious the DKD was, the higher the levels of IL6 and  TNFα  were (P<0.05). The levels of fasting blood glucose (FBG), serum creatinine (SCr) and blood urea nitrogen (BUN) in T2DM patients were significantly higher than those in patients of the control group. The more severe the DKD was, the higher the levels of FPC, SCr and BUN in serum were (P<0.05). Conclusion  The expression levels of NGAL and inflammatory cytokines increaseas T2DM DKD worsens.

Key words: diabetes mellitus, type2, apolipoproteins, chemokines, diabetic nephropathies