Effect of berberine hydrochloride on neurological function and serum malondialdehyde  in patients with acute ischemic stroke

doi:10.3969/j.issn.1004-583X.2016.10.012

Abstract

Abstract: ObjectiveTo explore the effect of berberine hydrochloride on neuralogical function and serum malondialdehyde (MDA) in patients with acute ischemic stroke. MethodsA total of 102 patients with acute ischemic stroke were randomly divided into two groups， including berberine group 52 cases and control group 50 cases. The control group received routine treatment while berberine group was given berberine hydrochloride 0.5 g three times a day on the basis of routine treatment for 14 days.Blood was collected from both groups before treatment and after treatment of 7 days and 14 days， then the serum MDA was determined with enzymelinked immunosorbent assay. Before treatment and after treatment of 7 days and 14 days， the neural function defect scale was scored by the US National Institutes of Health Stroke Scale (NIHSS). ResultsAfter treatment， the NIHSS score and MDA declined in both groups， and was significantly lower in berberine group than in control group (P<0.05). ConclusionBerberine hydrochloride significantly reduced MDA level in patients with acute ischemic stroke，the drug can improve the degree of neurological function deficit.

Key words: stroke, berberine hydrochloride, malondialdehyde

Chai Meijing1，Wang Pei2. Effect of berberine hydrochloride on neurological function and serum malondialdehyde in patients with acute ischemic stroke[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2016.10.012.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.10.012

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I10/1092

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Effect of berberine hydrochloride on neurological function and serum malondialdehyde in patients with acute ischemic stroke

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