Abstract: Objective  To analyze the combination of preoperative plasma levels of fibrinogen(Fbg) and neutrophiltolymphocyte ratio (COFNLR) with clinicopathologic characteristics as well as the prognosis of nonsmallcell lung cancer (NSCLC) patients after curative resection. Methods  The clinical data of 122 patients with NSCLC who underwent curative resection in our hospital were retrospectively analyzed. A total of  122 patients with NSCLC were divided into three groups based on the criteria of COFNLR: COFNLR 0 group， n=49; COFNLR1 group， n=41; COFNLR2 group， n=32.  The preoperative COFNLR was calculated by combing the fibrinogen and neutrophiltolymphocyte ratio (NLR). The relationship between the COFNLR and clinicopathological features was studied by chisquare test. The postoperative prognostic factors were analyzed using univariate KaplanMeier analysis and multivariate Cox proportional hazards model. Results  The COFNLR was significantly associated with sex， differentiation degrees， T staging， clinical staging（P<0.05）. Univariate analysis showed smoking history， differentiation degrees， T staging， lymph node metastasis， plasma levels of fibrinogen，NLR  and  COFNLR were associated with survival (P<0.05). Multivariate analysis identified that differentiation degrees， lymph node metastasis and COFNLR as independent prognostic factors of all the patients(all P<0.05).Conclusion  Preoperative elevated plasma level of COFNLR indicates tumor progression and poor prognosis in patients with NSCLC. The COFNLR may be a potentially new and useful blood marker for predicting tumor progression and the prognosis of patients with NSCLC.

Key words: carcinoma, nonsmallcell lung cancer, fibrinogen, neutrophil infiltration, lymphocytes, prognosis