Abstract: ObjectiveTo investigate gastroscope clinical characteristics， pathological characteristics and helicobacter pylori(Hp) infection status of patients with type 2 diabetes mellitus(T2DM). Besides，to explore the effect of diabetes course and HbA1c on gastric disease. MethodsWe selected 131 patients with T2DM who received gastroscopy and pathological examination，compared with non diabetic patients into the same period， to study gastroscopic clinical and pathological characteristics.Through HbA1c test，we observed the effects of glucose on the stomach disease. ResultsIn diabetes group，  the rate of gastritis with duodenal lesions and erosive gastritis was higher than that  of control group (P＜0.05).  Hp infection rate  in diabetes group was  47.3%(62/131)， helicobacter pylori infection rate  in control group  was 30.0%(37/112)(P＜0.05).In Hp negative diabetes group， the rate of gastritis with reflux esophagitis was higher than that of control group(P＜0.05). Diabetes course and HbA1c had no obvious effect on gastric disease. ConclusionIn patients with T2DM， Hp  infection rate was higher， the rate of  gastritis with duodenal lesions and erosive gastritis was higher， patients with histological features of precancerous lesions should maintain a high clinical vigilance. It is necessary to do endoscopic followup check and histopathological examination in a regular stage.

Key words: diabetes mellitus, gastroscope, stomach illness, helicobacter pylori