Abstract: ObjectiveTo explore changes of lipid metabolism， C reactive protein(CRP)， interleukin6(IL6) and IL10 in macrosomia of gestational diabetic mothers， in order to provide theoretical basis for reducing the risk of longterm cardiovascular disease in the offspring of GDM.MethodsFifty macrosomia born by mothers with gestational diabetes mellitus were selected as observing group， and 50 normal fullmonth neonatus born by mothers without pregnancy complication served as normal control. Levels of total cholesterol(TC)， triglyceride(TG)， low density lipoprotein cholesterol(LDLC），high density lipoprotein cholesterol(HDLC）， CRP， IL6 and IL10 were measured within 24 hours after birth. ResultsThe levels of TC， TG and LDLC in observing group were significantly higher than those in control group (P<0.01). HDLC showed no significant difference between observing group and control group (P>0.05). Levels of CRP， IL6 and IL10 showed no significant difference between observing group and control group (P>0.05). ConclusionMacrosomia of gestational diabetic mothers tended to develop lipid metabolism disorder， and levels of CRP， IL6 and IL10 had no obvious change.

Key words: diabetes, gestational, neonatal, macrosomia, serum lipid, Creactive protein, interleukin10, interleukin6