Abstract: ObjectiveTo compare the efficacy and safety of soft and hard channel minimally invasive hematoma evacuation combined with two thrombolytic drugs in treatment of hypertensive cerebellar hemorrhage. MethodsForty patients with hypertensive cerebellar hemorrhage hospitalized in the hospital were enrolled. Two thrombolytic drugs (alteplase and urokinase) were used to assist two minimally invasive surgical therapies， the patients were randomized into four groups， each group 10 cases， and the cases were collected for clinical analysis. Hematoma volume and brain edema volume， the changes to the National Institutes of Health Stroke Scale (NIHSS)， the changes to Glasgow Outcome Scale (GOS)， and the changes to ADL Barthel Index (BI) of four groups were analyzed before and after treatment. Results The clearance of hematoma， NIHSS score and BI score  in softchannel 1 group  were statistically significant compared with those in the other three groups. In  GOS score， softchannel 1 group  was statistically different compared with only hardchannel 1 group.  The length of hospital stay in softchannel 1 group was statistically significant  compared with that in two hardchannel groups. ConclusionThe therapy can improve the remedy rate of cerebellar hemorrhage.

Key words: intracranial , hemorrhage, hypertensive；hematoma, surgical procedure, minimally invasive, confined spaces, urokinasetype plasminogen activator