Abstract: Objective  In order to analyze the clinical characteristics of patients with chronic obstructive pulmonary disease (COPD) and lung cancer， to improve the clinical understanding of COPD with lung cancer. Methods  Retrospective analysis was performed in 98 patients of COPD with lung cancer and the same pospitalized period 108 patients with simple COPD. The clinical data of two groups were analyzed with statistics. Results  COPD combined with lung cancer patients were significantly higher in hemoptysis or sputum bloody， chest pain， atelectasis， hoarseness， pleural effusion， weight loss than patients with COPD alone (P<0.05);The male patients with COPD combined with lung cancer were significantly more than COPD alone(86.7% vs 71.3%，P<0.05)；Patients with COPD were older than COPD with lung cancer (P<0.01)；The smoking index of COPD with lung cancer group was significantly higher than that of COPD alone (P<0.01)；The lung function classification of COPD patients with lung cancer group in the first and second grade were significantly more than those of COPD alone（62.9% vs 54.3%，P=0.047；78.7% vs 21.3%，P＜0.01）；COPD patients with lung cancer group， the highest proportion of lung squamous cell carcinoma (43.9%)， men with lung squamous cell carcinoma was common (48.2%)， women with lung adenocarcinoma was more common (53.8%). Conclusion  When patients with  a history of COPD had hemoptysis or sputum bloody， chest pain， atelectasis， hoarseness， pleural effusion， weight loss of clinical manifestations and signs， the possibility of lung cancer  should be alerted. COPD combined with lung cancer occurs in a large number of male patients with smoking， airway obstruction in patients with COPD prone to lung cancer， lung squamous cell carcinoma is the most common pathological type.

Key words: pulmonary disease, obstructive；lung neoplasms；signs and symptoms