Abstract: Objective  To analyze the incidence and prognosis of patients with acute kidney injury (AKI) in emergency intensive care unit (EICU) and to compare the clinical characteristics of patients with sepsis and nonsepsis and explore the prognosis of patints with AKI. Methods  This study analyzed the baseline characteristics and laboratory data of 335 patients in EICU from January 1, 2014 to October 31, 2016. AKI patients were allocated into AKI+sepsis group and AKIsepsis group for  analysis of clinical characteristics. The AKI severity was classified according to the KDIGO (Kidney Disease: Improving Global Outcomes) guidelines.The multivariable Logistic regression was applied to investigate risk factors for the progression and death of AKI. Results  Of 335 patients, 175 cases (52.2%) developed AKI. Among them, there were 114 cases of septic AKI patients and 61 cases of nonseptic AKI patients. Patients with septic AKI had higher illness severity scores than nonseptic AKI patients,  Vasoactive therapy and mechanical ventilation were used more commonly in septic AKI patients. The multivariable Logistic regression analysis revealed that the development of AKI was associated with infection, SOFA score, use of diuretics and cardiovascular. Infection, shock and the severity of AKI were identified as the risk factors for 28day mortality. Conclusion  AKI patients have high morbidity and mortality in EICU,  while patients with septic AKI  had  a worse prognosis than nonseptic AKI patients. A variety of factors are related to the prognosis of AKI.

Key words: kidney diseases, kidney , function tests, sepsis, clinical characteristics, prognosis