Table of Content

05 May 2016, Volume 31 Issue 5

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Current treatment and future progress of ankylosing spondylitis

Wen Qiongfang， Huang Feng

2016, 31(5):  465-469.  doi:10.3969/j.issn.1004-583X.2016.05.001

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Ankylosing spondylitis (AS) is a chronic， progressive， inflammatory disorder that mainly affects axial skeleton. Researches of the etiology and pathogenesis of AS in the past years greatly contributed to the rapid progress in diagnosis and treatment. Meanwhile， the combination of standardized use of traditional agents and TNF alpha inhibitors has rewritten the medical history of AS. Early， adequate and regular therapy and functional exercise can inhibit inflammation， delay the radiographic progression and new bone formation immediately. Further studies are required to confirm the efficacy and safety of novel biological agents.

Treatment comments on lupus  nephritis: guidelines  and advances

Wang Li， Li Mengtao，Zhang Xuan，Zeng Xiaofeng，Zhang Wen， Zhang Fengchun

2016, 31(5):  470-474.  doi:10.3969/j.issn.1004-583X.2016.05.002

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Recently， great advances have been made in the treatment of lupus nephritis (LN). In 2012， the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) published their respective recommendations and guidelines of LN treatment. From 2013， there have been a lot of novel credible results of clinical trials on LN treatment， which were updating rheumatologists' opinions. In this article， the authors analyzed the two classic recommendations and summarized the recent progresses in order to provide references for clinical treatment of LN.

Advances in diagnosis and  therapy of  systemic lupus erythematosus

He Jingjing，Qiao Yongxia， Wang Yanru，Liu Aijing

2016, 31(5):  475-481.  doi:10.3969/j.issn.1004-583X.2016.05.003

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Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease that affects multiple organs and is characterized by the presence of variety of autoantibodies， episodic flares and elevated mortality despite therapy. The etiology of SLE remains poorly known. In recent years， a wide range of mechanismsdirected researches are being developed， coupled with the progress of diagnostic performance and treatment， as well as remarkable improvement in prognosis. Here， we provide an update on the development of classification criteria and treatment  regimens of SLE，aiming to improve the monitoring， management and， ultimately， the prognosis of SLE.

Treatment of Sjogren syndrome: the old and the new

Zhang Fengxiao

2016, 31(5):  482-485.  doi:10.3969/j.issn.1004-583X.2016.05.004

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Sjogren syndrome(SS) is a set of heterogeneous systemic autoimmune diseases characterized by dry mouth and dry eyes. There is often systemic involvement(extraglandular  manifestications). A variety of topical and systemic drugs are available to treat SS， although no evidencebased therapeutic guidelines are available. The therapeutic management of pSS is based on symptomatic treatment of glandular manifestations and on the use of diseasemodifying drugs for systemic involvement. Because mounting evidence points to a central pathophysiologic role for B cells， Bcell depletion is being evaluated as a treatment of SS. This review focuses on the major therapeutic discoveries of the last few years to offer practical methods for the treatment of patients with SS.

Modern treatment strategies and methods for rheumatoid arthritis

Li Zhenbin

2016, 31(5):  486-489.  doi:10.3969/j.issn.1004-583X.2016.05.005

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Rheumatoid arthritis is a chronic systemic autoimmune disease， which remains a difficult condition to manage due to unknown etiology. Reaching the standard control (treattotarget) is the main strategy of RA treatment. Longterm maintenance of remission is very important for the prevention of joint functional disability. The strategies and methods of target control include early treatment， combination therapy， targeted therapy， individualized treatment， chronotherapy and Chinese medicine treatment.

Therapeutic advancements of biologic agents in rheumatic disease

Jin Hongtao， Gao Lixia

2016, 31(5):  490-495.  doi:10.3969/j.issn.1004-583X.2016.05.006

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Biological agent is a recombinant product that is selectively targeted to the immune response or to the inflammatory process， or to the target of a monoclonal antibody or a natural inhibitor of the target. The biologic drugs have wide variety， the major targets of most biologic therapies are cytokines， B cells and costimulation molecules， including tumor necrosis factor (TNF) inhibitors，antiinterleukin6 receptor monoclonal antibody， antiCD20 antibodies rutximab and other drugs. They are prescribed for the treatment of rheumatoid arthritis， ankylosing  spondylitis，systemic lupus erythematosus and other autoimmune disease.The use of biological agents should pay attention to safety. It is necessary to screen tuberculosis and exclude active infections and cancer before the use of biologic agents. Reduction dose or stopping biological drug need to be discussed.

Pay attention to the influence and prevention strategy of hyperuricemia on metabolic syndrome and cardiovascular disease

Zhang Mingfeng, Guo Huifang, Gao Lixia

2016, 31(5):  496-500.  doi:10.3969/j.issn.1004-583X.2016.05.007

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Uric acid is the ending product of purine metabolism. Increased serum uric acid (SUA) affects the stability of atheromatous plaque and increases the incidence of myocardial infarction, heart failure and allcause mortality of patients with coronary heart disease (CHD). Especially in female patients, the incidence of CHD has increased significantly. Using normotensive children for comparison, the risk of showing prehypertension or hypertension increases by at least 50% for each 1 mg/L SUA increase in adolescence. The morbidity of hypertention in male is higher than that in female. Hyperuricemia (HUA) also adds the risk of diabetes, abnormal glucose tolerance and diabetic nephropathy. To some extent, HUA aggravates symptoms of metabolic syndrome such as insulin resistance, obesity or lipid metabolic disorders. Although HUA increases prevalence risk of cardiovascular disease, there is no consensus recommendation for the treatment of asymptomatic HUA at home and abroad.

Diagnosis and treatment advances of  IgG4related disease

Gao Lixia

2016, 31(5):  501-505.  doi:10.3969/j.issn.1004-583X.2016.05.008

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IgG4 related disease (IgG4RD) is a kind of chronic systemic autoimmune disease， whose etiology is unknown. The clinical spectrum of IgG4RD is wide. The disease always involves systemic glandular organs， retroperitoneum， kidney， pituitary gland and lymph nodes. IgG4RD is characterized by swelling and fibrosclerosing change of affected organs，elevated serum IgG4 level， a large number of  lymphocytes and IgG4 positive plasma cells infiltration in involved organ and tissue．The diagnosis is confirmed by biopsy， the histopathological features include: dense lymphocytes and plasmacytes infiltration， storiform fibrosis and sclerosis， obliterative phlebitis. Glucocorticoids are the firstline agent for remission induction，some IgG4RD patients require the use of immunosuppressive  drugs or biological agents.

Update of diagnosis and treatment in connective tissue disease

Li Na， Zhang Yanping

2016, 31(5):  506-511.  doi:10.3969/j.issn.1004-583X.2016.05.009

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Interstitial lung disease (ILD) is now increasingly recognized as a frequent and serious complication associated with connective tissue disease (CTD)， and severely influences the life quality of patients. There are substantial differences in the clinical presentations， pathological types and imaging appearances of ILD in each specific CTD. Diagnosis and treatment timely is crucial for the prognosis of patients. The research progress of CTDILD in rencent years was updated in this artical.

Nailfold videocapillaroscopy in rheumatic diseases

Sun Lin， Liu Xiangyuan

2016, 31(5):  512-515.  doi:10.3969/j.issn.1004-583X.2016.05.010

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Nailfold capillary microscopy is a simple， noninvasive and inexpensive method， which can facilitate showing microvascular involvement and follow up. It is useful in staging scleroderma patients and also correlates with digital ulcer and lung involvement.In other rheumatic diseases， such as dermatomyositis，undifferentiated connective tissue disease and systemic lupus erythematosus， we can also detect micro/cardiovascular abnormalities under nailfold capillaroscopy.

Influencing factor analysis of left atrial thrombus or spontaneous  echo contrast in patients with nonvalvular atrial fibrillation

Xiao Pengfei，Li Guangping，Ye Lan，Xu Gang，Liu Xia

2016, 31(5):  516-519,523.  doi:10.3969/j.issn.1004-583X.2016.05.011

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Objective To investigate influencing factors of left atrial thrombus(LATH) or spontaneous echo contrast (SEC) in patients with nonvalvular atrial fibrillation (NVAF). Methods One hundred and thirty patients with NVAF were collected in this study.CHA2DS2VASc risk scores for each patient were calculated.The baseline clinical data were detected，  including gender， age，concomitant diseases， laboratory parameters and ecocardiography.The patients were divided into left atrial thrombus or spontaneous echo contrast positive group and negative group according to the result of transeophageal ecocardiography（TEE）.The parameters between the two groups were compared，receptoroperating curves（AUC） were used to test the value of CHA2DS2VASc score，left atrial diameter(LAD)，left atrial appendage filling velocity and left atrial appendage emptying velocity predicting left atrial thrombus or spontaneous echo contrast．Logistic analysis was used to find the independent predictor of left atrial thrombus or spontaneous echo contrast. Results There were significant differences in left atrial diameter(LAD)， left ventricular enddiastolic diameter (LVEDD)，left ventricular ejection fraction(LVEF)，the proportion of persistent atrial fibrillation，previous history of stroke or transient ischemic attack (TIA)， body mass index（BMI），CHA2DS2VASc score，left atrial appendage emptying velocity，left atrial appendage filling velocity between the two groups.In multivariate analysis，LAD>40.0 mm(P=0.01)， left atrial appendage emptying velocity＜54.15  cm/s(P<0.01)， BMI≥25(P<0.01) were independently associated with left atrial thrombus or SEC in patients with NVAF.The AUC of LAD to predict left atrial thrombus or SEC was 0.845(95%CI=0.7760.913，P<0.01)，the sensitivity and specificity were 67.6％  and  88.7％.The AUC of left atrial appendage emptying velocity to predict left atrial thrombus or SEC was 0.851(95%CI=0.7810.921，P<0.01)，the sensitivity and specificity were 83.9％  and   74.9％. Conclusion  LAD>40.0 mm，left atrial appendage emptying velocity＜54.15  cm/s are independent risk factors of left atrial thrombus or spontaneous echo contrast in patients with NVAF.

Analysis about risk factors of malignant ventricular arrhythmias of STelevation myocardial infarction

Bai Chengxiong， He Shaobo， Fu Jie

2016, 31(5):  520-523.  doi:10.3969/j.issn.1004-583X.2016.05.012

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Objective To analyze the risk factors of malignant ventricular arrhythmias (MVA) of STelevation myocardial infarction. Methods Retrospective analysis was made in 158 cases of patients  in our hospital who had clear and definite diagnosis for STelevation myocardial infarction. The patients were divided into study group (MVA  incidence， 32 cases) and control group (no MVA incidence， 126 cases) according to the incidence of  MVA 48 hours after primary PCI. The clinical indicators such as basic clinical  indicators， ECG， laboratory test， coronary angiography of two groups were counted and compared. Results The proportion of patients with diabetes，the level of  blood glucose， level of serum creatinine， level of leukocyte， level of neutrophil cell and proportion of  heart function Klillip grade Ⅳ of patients in study group were significantly higher than those in control group (P<0.05)， while the serum potassium concentration was significantly lower than that of control group (P<0.05).The risk factors of  MVA of STelevation myocardial infarction included heart function Klillip grade Ⅳ， leukocyte count was greater than or equal to 11.040×109/L，neutrophils count was greater than or equal to 8.155×109/L， the level of blood glucose was more than or equal to 9.58  mmol/L， serum potassium was less than or equal to 3.13  mmol/L， creatinine was more than or equal to  96.93  μmol/L(P<0.01). Conclusion  The clinical intervention measures of STelevation myocardial infarction in view of the above risk factors should be strengthened， the incidence of  MVA will be reduced， the prognosis of patients will be improved.

Application of fourstep massage method in maintenance hemodialysis patients with thrombosis of arteriovenous fistula

Lu Hua， Huo Pengfei， Liu Qian， Liu Jing， Guo Gengxin

2016, 31(5):  524-527,531.  doi:10.3969/j.issn.1004-583X.2016.05.013

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Objective  To investigate the curative effect of fourstep massage method in maintenance hemodialysis patients with thrombosis of arteriovenous fistula. Methods  Thirtysix patients with acute thrombosis in forearm autogenous internal arteriovenous fistula were enrolled in this study and separated into the control group (18 cases) and the research group (18 cases). Routine massage method was implemented in control group， while fourstep massage method was implemented in research group. Both of them were followed by continous intravenous pumping of urokinase. The success rate of thrombolytic therapy， blood flow volume during the first time dialysis after recanalization， duration treatment， and the occurrence rate of hematomas were compared between two groups. Results  In research group， the recanalization rate and blood flow volume during the first time dialysis were significantly higher than those in control group， while the treatment duration and the occurrence rate of hematomas were significantly lower than those in control group(P<0.05).Conclusion  For maintenance hemodialysis patients with acute thrombosis in forearm autogenous internal arteriovenous fistula， fourstep massage method combined with urokinase  showed higher success rate， faster recanalization and fewer hematomas rate in thrombolysis and it  worths  clinical promoting.

Clinical significance of high expression of angiotensin converting enzyme in tumor tissue of patients with brain glioma

Li Jin， Sun Jie， Zhao Nan， Wu Jun， Liu Jun，Ma Gang

2016, 31(5):  528-531.  doi:10.3969/j.issn.1004-583X.2016.05.014

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Objective  To investigate the expression of angiotensin converting enzyme (ACE) and clinical significance in evaluating the prognosis in patients with different grades of brain glioma. Methods  The expression levels of ACE mRNA and protein in 48 patients with different grades of brain glioma and 22 cases of human normal brain tissues were detected by realtime fluorescence quantitative PCR and western blot. According to the criteria of the World Health Organization， all 48 patients with different grades of brain glioma， including 8 cases (grade Ⅰ)， 18 cases (grade  Ⅱ)， 16 cases (grade  Ⅲ) and 6 cases (grade  Ⅳ)， were observed. Results  The expression levels of ACE mRNA and protein in brain glioma tissues were significantly higher than those of normal brain tissues (P<0.05). The expression levels of ACE mRNA in the brain glioma tissues were significantly higher in patients with grade  ⅢⅣ  than in patients with grade ⅠⅡ (P<0.05). Conclusion  ACE is highly expressed in the tumor tissues of patients with brain glioma， which is closely related to tumors grade. These findings suggest that the high expression of ACE in glioma may provide clinical reference value in evaluating the prognosis of the patients with brain glioma.

Clinical efficacy of repetitive transcranial magnetic stimulation in treatment of post stroke depression and magnetic resonance spectroscopy analysis

Zhou Lihua，Tian Qing，Chen Xun，Zhou Qian，Ye Hong

2016, 31(5):  532-535.  doi:10.3969/j.issn.1004-583X.2016.05.015

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Objective  To investigate the effect of different frequency repetitive transcranial magnetic stimulation (rTMS) in patients with post stroke depression(PSD). Methods  Seventythree PSD patients who met  the third edition of the Chinese Classification of Mental Disorders(CCMDⅢ)，were examined by Hamilton Depression Scale (HAMD) at enrollment and four weeks after treatment，and examined by proton magnetic resonance spectroscopy (1HMRS) four weeks after treatment.The patients were divided into high frequency group(24 cases)，low frequency group(24cases) and sham stimulation group(25 cases)，the former two groups respectively got rTMS high or low frequency treatment. But sham stimulation group was giren the sounds of same frequency as high frequency groups，but no magnetic stimulation. Results  ① After treatment， HAMD score reduced in high frequency group (13.5±1.6) scores and low frequency group (13.1±1.7) scores， there was no significant difference between two groups.The difference was statistically significant between the two groups and the sham stimulation group (16.3±1.4) scores (P<0.01).The HAMD score of sham group was not significantly improved. ② After treatment， there were no significant difference in Cho/Cr ratio between the three groups of patients with frontal lobe， hippocampus japonicas and thalamus (P>0.05). Conclusion  Both high frequency of  rTMS  and low frequency can improve the status of depression in patients with PSD.There were no significant differences between  two groups.

Relationship between uric acid and cognitive impairment in elderly patients with cerebral infarction

Xu Lei1, Yu Ming1, Tan Hua2

2016, 31(5):  536-538,542.  doi:10.3969/j.issn.1004-583X.2016.05.016

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Objective  To investigate the incidence of cognitive impairment and its correlation with uric acid in elderly patients with cerebral infarction. Methods  A total of 102 elderly patients with cerebral infarction were selected in clinical practice. Based on the MoCA, all patients were divided into two groups: cognitive impairment group and normal cognitive group. Differences in the uric acid and other related factors were compared between two groups, and logistic regression analysis was used to estimate the correlation between uric acid and cognitive impairment. Results   The incidence of cognitive impairment among all 102 patients was 58.8% (60 cases). Serum uric acid was significantly higher in cognitive impairment group than in normal group (P＜0.01). The multiple logistic regression analysis showed that high uric acid was associated with cognitive impairment (OR=1.043, 95%CI  1.0201.067,P＜0.01). Conclusion   The incidence of cognitive impairment in elderly patients with cerebral infarction was higher, and uric acid was considered  the risk factor of cognitive impairment in elderly patients with cerebral infarction.

Pilot clinical study on the efficacy of liraglutide in treating polycystic ovary syndrome patients with type 2 diabetes mellitus

Gao Lihua， Zhang Cailan，Liu Xuyang， Li Jing， Liu Jia， Zhong Chengfu

2016, 31(5):  539-542.  doi:10.3969/j.issn.1004-583X.2016.05.017

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Objective  To investigate the efficacy of liraglutide and metformin on metabolic and endocrine parameters in polycystic ovary syndrome (PCOS) patients with type 2 diabetes mellitus (T2DM). Methods  A total of 62 PCOS patients with T2DM were randomly divided into two groups， and liraglutide (1.21.8  mg/d ) or metformin (0.5  g/d) were used for 12 weeks， respectively. Metabolic parameters and sexual hormones were evaluated before and after treatment. Results  After 12 weeks’  treatment， the levels of FPG， 2 hPG， HbA1c， BMI and HOMAIR  were significantly improved in both groups (P<0.05)， and the improvement in liraglutide group was superior than that in metformin group (P<0.05). After treatment， the levels of LH and T were significantly reduced in both groups (P<0.05)， however， there were no significant difference in sexual hormones in pretreatment and posttreatment(P>0.05). Conclusion  Liraglutide can improve hyperglycemia and insulin resistance in PCOS patients with T2DM， and can also be helpful in improving hyperandrogenism.

Influence of  Wnt inhibitor XAV939 on  proliferation and apoptosis of small cell lung cancer H446 cells

Guo Wenxuan， Zhu Yingqian， Shen Fangzhen， Wang Xiaoni， Pan Fei， Chen Jing

2016, 31(5):  543-546.  doi:10.3969/j.issn.1004-583X.2016.05.018

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Objective  To investigate the influence of the Wnt inhibitor XAV939 on the proliferation and apoptosis of small cell lung cancer (SCLC) H446 cells. Methods  MTT assays was used to detect the growth inhibition rate of cells in each group and to explore the optimized drug concentration. Flow cytometry was used to detect the impact of the XAV939 effects on cell apoptosis. Results  The XAV939 inhibited the growth of H446 in a dosedependent manner (P<0.01)， but cisplatin inhibited the growth of H446 in a time and dosedependent manner (P<0.01). The combination of both drugs inhibited the growth of H446 more significantly. In addition， the percentage of apoptosis of H446 cells increased with the increased concentration of XAV939(P<0.05). Conclusion  The data indicated that the XAV939 inhibited the growth of SCLC H446 cells by Wntinduced cell apoptosis， and it may become a helpful treatment tool for SCLC.

Factors analysis  of patients prognosis associated  with advanced nonsmall cell lung cancer

Qu Zhuohui1，Wang Yuehui1，Gong Jing2，Liu Yunpeng2，Qu Xiujuan2，Qin Ying1

2016, 31(5):  547-550.  doi:10.3969/j.issn.1004-583X.2016.05.019

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Objective  To study the factors associated with prognosis of advanced nonsmall cell lung cancer(NSCLC)．Methods  Retrospective study was performed for clinical data of 234 patients with advanced NSCLC. The potential prognostic factors were evaluated by univariate and multivariate analyses. Results  Of 234 advanced NSCLC cases，six  factors such as gender，age，smoking status， performance status(PS)，pathological type and clinical stage were analyzed by univariate analysis， the results showed that the relative risk of PS was 1.980(95%CI  1.4822.646，P<0.05)，and the relative risk of smoking status was 1.355(95%CI  1.0291.784，P<0.05)， indicating PS and smoking status were related to the prognosis.Further multivariate analysis of the above two factors showed that the relative risk of PS was 2.085(95%CI  1.5552.796，P<0.05)，and the relative risk of smoking status was 1.464(95%CI  1.1091.934，P<0.05)，PS and smoking status were independent prognostic factors. Conclusion  PS and smoking are the independent factors associated with prognosis of advanced NSCLC．

Clinical study of  docetaxel combined with oxaliplatin in advanced nonsmall cell lung cancer

Zhang Yusheng， Wang Yaning，He Xia

2016, 31(5):  551-553,558.  doi:10.3969/j.issn.1004-583X.2016.05.020

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Objective To investigate the clinical effect of  docetaxel combined with oxaliplatin in advanced nonsmall cell lung cancer. Methods  A total of 118 patients with advanced nonsmallcell lung cancer  were randomly divided into observation group and control group， 59 cases in each group. The control group was treated with cisplatin combined with docetaxel and the observation group was treated with oxaliplatin combined with docetaxel. The differences of solid tumor efficacy， time to progression， overall survival time， and adverse reaction rate of patients in both groups were compared. Results  The rates of complete remission， partial remission and clinical effect in observation group were 11.9% (7/59)， 47.5% (28/59) and 59.3% (35/59)， respectively， which were higher than 8.5% (5/59)，39.0% (23/59) and 47.5% (28/59) in control group， respectively (P>0.05). The time to progression and overall survival time in observation group were (12.17±0.98)  months and  (20.07±2.38)  months， respectively， which were significantly higher than (8.48±0.68) months and (16.07±2.78) months in control group， respectively (P<0.05). The rates of bone marrow depression， digestive tract abnormalities， decreased white blood cells， peripheral nerve toxicity， liver function abnormalities and other adverse reactions were significantly lower in observation group than in control group， and the degree was significantly improved in control group (P<0.05).Conclusion  Docetaxel combined with oxaliplatin has an affirmative clinical efficacy in advanced nonsmall cell lung cancer with lower adverse reactions and is one of the effective measures in the treatment of advanced nonsmall cell lung cancer.

Effect of two analgesic and sedation strategies in  treating severe handfootmouth children with mechanical ventilation

Chen Dongmei， Tian Qingling， Zhang Shuang， Zhang Runchun， Song Peng， Zhang Qing， Feng Xue

2016, 31(5):  554-558.  doi:10.3969/j.issn.1004-583X.2016.05.021

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Objective  To investigate the effect of two analgesic and sedation strategies (midazolam and midazolam combined with fentanyl) in treating severe handfootmouth children with mechanical ventilation. Methods  A total of 190 children with severe handfootmouth disease treating with mechanical ventilation were selected. According to treatment program， all patients were divided into two groups， including 95 patients with midazolam  as M   group and 95 patients with midazolam combined with fentanyl as M+F group. Therapeutic effect was compared between both groups. Results  After treatment， ramsay scores were  within a reasonable range in both groups. After sedation of 2 h， 4 h， 6 h， 8 h， 10 h and 12 h， Ramsay score was closer to ideal sedation end point in M+F group than in M group (P<0.01). After sedation， PAED score was significantly decreased in both groups. As sedation time prolonged， PAED score decreased more significantly. After sedation of 2 h， 4 h， 6 h， 8 h，10 h and 12 h， PAED score was significantly lower in M+F group than in M group (P<0.01). Spontaneous breathing time， eye opening time， accurately complete instruction time， extubation time and orientation recovery time were significantly earlier in M+F group than in M  group (P<0.01). Mechanical ventilation time， ICU hospitalization time and total hospitalization time were significantly decreased in M+F group than in M group (P<0.01). Conclusion  Midazolam combined with fentanyl can obviously relieve pain， reduce agitation， shorten recovery time and treatment time and it is worthy of clinical use.

Study of intravoxel incoherent motion imaging in common renal cell carcinoma

Chu Kunyi1a， Zheng Yuanyuan1a， Zhang Hui1b， Feng Pingyong2， He Ai2， Zou Yuyan2， Zuo Yuqiang3

2016, 31(5):  559-562,565.  doi:10.3969/j.issn.1004-583X.2016.05.022

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Objective  To use intravoxel incoherent motion(IVIM) diffusionweighted imaging of renal cell carcinoma (RCC) for comparing their imaging difference， so as to provide more valuable imaging basis for guiding clinical individualized treatment. Methods  A retrospective study was made in 49 patients with RCC  demonstrated by surgical pathology and imaged at 3.0T MRI using 8 b values for diffusionweighted imaging， the values of ADC and IVIM parameters were compared between different subtypes of RCC. Results  The values of ADC， pseudodiffusivity coefficient (D*) and perfusion fraction (f) of clear cell RCC(ccRCC)  or chromophobe RCC(chRCC) compared with papillary RCC(pRCC) had statistically significant difference (P＜0.05)， but the value of tissue diffusivity (D) demonstrated no significant difference. Conclusion  ccRCC and chRCC are hypervascular tumors， the values of ADC and IVIM parameters were no significant difference in the solid portion between ccRCC and chRCC. The values of ADC， D*and f were lower in pRCC than those of  ccRCC and chRCC. The value of D demonstrates no significant difference between common subtypes of RCC.