Clinical significance of high expression of angiotensin converting enzyme in tumor tissue of patients with brain glioma

doi:10.3969/j.issn.1004-583X.2016.05.014

Abstract

Abstract:

Objective To investigate the expression of angiotensin converting enzyme (ACE) and clinical significance in evaluating the prognosis in patients with different grades of brain glioma. Methods The expression levels of ACE mRNA and protein in 48 patients with different grades of brain glioma and 22 cases of human normal brain tissues were detected by realtime fluorescence quantitative PCR and western blot. According to the criteria of the World Health Organization， all 48 patients with different grades of brain glioma， including 8 cases (grade Ⅰ)， 18 cases (grade Ⅱ)， 16 cases (grade Ⅲ) and 6 cases (grade Ⅳ)， were observed. Results The expression levels of ACE mRNA and protein in brain glioma tissues were significantly higher than those of normal brain tissues (P<0.05). The expression levels of ACE mRNA in the brain glioma tissues were significantly higher in patients with grade ⅢⅣ than in patients with grade ⅠⅡ (P<0.05). Conclusion ACE is highly expressed in the tumor tissues of patients with brain glioma， which is closely related to tumors grade. These findings suggest that the high expression of ACE in glioma may provide clinical reference value in evaluating the prognosis of the patients with brain glioma.

Key words: glioma, peptidyldipeptidase A, prognosis

Li Jin， Sun Jie， Zhao Nan， Wu Jun， Liu Jun，Ma Gang. Clinical significance of high expression of angiotensin converting enzyme in tumor tissue of patients with brain glioma[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2016.05.014.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.05.014

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I5/528

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Clinical significance of high expression of angiotensin converting enzyme in tumor tissue of patients with brain glioma

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