脑微出血机制与危险因素的研究进展

doi:10.3969/j.issn.1004-583X.2021.08.015

摘要/Abstract

摘要：

脑微出血(cerebral microbleeds, CMBs)增加了卒中、认知障碍等相关疾病的风险。现就CMBs的流行病学现状、影像学特点、危险因素、发病机制等方面进行综述,为CMBs的深入探究及科学防治提供依据。

中图分类号:

R743

王慧玲, 郑连红, 王萌. 脑微出血机制与危险因素的研究进展[J]. 临床荟萃, 2021, 36(8): 749-752.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.08.015

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I8/749

参考文献 32

[1]	Cannistraro RJ, Badi M, Eidelman BH, et al. CNS small vessel disease: A clinical review[J]. Neurology, 2019, 92(24):1146-1156. doi: 10.1212/WNL.0000000000007654 pmid: 31142635
[2]	Han F, Zhai FF, Wang Q, et al. Prevalence and risk factors of cerebral small vessel disease in a Chinese population-based sample[J]. J Stroke, 2018, 20(2):239-246. doi: 10.5853/jos.2017.02110 URL
[3]	Haji S, Planchard R, Zubair A, et al. The clinical relevance of cerebral microbleeds in patients with cerebral ischemia and atrial fibrillation[J]. J Neurol, 2016, 263(2):238-244. doi: 10.1007/s00415-015-7966-2 URL
[4]	De Guio F, Jouvent E, Biessels GJ, et al. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease[J]. J Cereb Blood Flow Metab, 2016, 36:1319-1337. doi: 10.1177/0271678X16647396 URL
[5]	Greenberg SM, Vernooij MW, Cordonnier C, et al. Cerebral microbleeds: A guide to detection and interpretation[J]. Lancet Neurol, 2009, 8(2):165-174. doi: 10.1016/S1474-4422(09)70013-4 pmid: 19161908
[6]	Kikuno M, Ueno Y, Shimizu T, et al. Underlying embolic and pathologic differentiation by cerebral microbleeds in cryptogenic stroke[J]. J Neurol, 2020, 267(5):1482-1490. doi: 10.1007/s00415-020-09732-4 URL
[7]	李永琴, 陈飞, 张微微, 等. 脑微出血及其分布与肾功能的相关性分析[J]. 中华老年心脑血管病杂志, 2019, 21(9):926-929.
[8]	Patwa J, Flora SJS. Heavy metal-induced cerebral small vessel disease: Insights into molecular mechanisms and possible reversal strategies[J]. Int J Mol Sci, 2020, 21(11):3862. doi: 10.3390/ijms21113862 URL
[9]	Iadecola C, Parikh NS. Blood pressure ups and downs foreshadow cerebral microangiopathy[J]. J Am Coll Cardiol, 2020, 75(19):2400-2402.
[10]	Lyu L, Shen J, Zeng C, et al. Cerebral microbleeds are associated with blood pressure levels in individuals with hypertension[J]. Clin Exp Hypertens, 2020, 42(4):328-334. doi: 10.1080/10641963.2019.1665673 URL
[11]	Thorn LM, Shams S, Gordin D, et al. Clinical and MRI features of cerebral small-vessel disease in type 1 diabetes[J]. Diabetes Care, 2019, 42(2):327-330. doi: 10.2337/dc18-1302 pmid: 30552131
[12]	Lei C, Zhong L, Ling Y, et al. Blood glucose levels are associated with cerebral microbleeds in patients with acute ischaemic stroke[J]. Eur Neurol, 2018, 80(3/4):187-192. doi: 10.1159/000494990 URL
[13]	Patet C, Suys T, Carteron L, et al. Cerebral lactate metabolism after traumatic brain injury[J]. Curr Neurol Neurosci Rep, 2016, 16(4):31. doi: 10.1007/s11910-016-0638-5 URL
[14]	MacGregor Sharp M, Saito S, Keable A, et al. Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia[J]. Acta Neuropathol Commun, 2020, 8(1):131. doi: 10.1186/s40478-020-01009-1 URL
[15]	Zhou YN, Gao HY, Zhao FF, et al. The study on analysis of risk factors for severity of white matter lesions and its correlation with cerebral microbleeds in the elderly with lacunar infarction[J]. Medicine (Baltimore), 2020, 99(4):e18865. doi: 10.1097/MD.0000000000018865 URL
[16]	Fan D, Chaudhari NN, Rostowsky KA, et al. Post-traumatic cerebral microhemorrhages and their effects upon white matter connectivity in the aging human brain[J]. Annu Int Conf IEEE Eng Med Biol Soc, 2019, 2019:198-203. doi: 10.1109/EMBC.2019.8857921 pmid: 31945877
[17]	Zhang H, Deng J, Sun N, et al. Effect of coagulation function on cerebral microbleeds in intracerebral hemorrhage[J]. Brain Behav, 2020, 10(6):e01634.
[18]	Elkhatib THM, Elsaid AF, Al-Molla RM, et al. Prevalence and associated risk factors of cerebral microbleeds in Egyptian patients with acute ischemic stroke and atrial fibrillation[J]. J Stroke Cerebrovasc Dis, 2020, 29(5):104703. doi: S1052-3057(20)30074-4 pmid: 32111450
[19]	Alaa El Din A, Debeaumarche H, Thouant P, et al. Cerebral microbleeds and acute myocardial infarction: Screening and disease progression[J]. Int J Cardiol Heart Vasc, 2020, 28:100531.
[20]	Parikh NS, Dueker N, Varela D, et al. Association between PNPLA3 rs738409 G variant and MRI cerebrovascular disease biomarkers[J]. J Neurol Sci, 2020, 416:116981. doi: 10.1016/j.jns.2020.116981 pmid: 32592869
[21]	Silva RMFLD, Miranda CM, Liu T, et al. Atrial fibrillation and risk of dementia: Epidemiology, mechanisms, and effect of anticoagulation[J]. Front Neurosci, 2019, 13:18. doi: 10.3389/fnins.2019.00018 URL
[22]	Graff-Radford J, Lesnick T, Rabinstein AA, et al. Cerebral microbleed incidence, relationship to amyloid burden: The mayo clinic study of aging[J]. Neurology, 2020, 94(2):e190-e199. doi: 10.1212/WNL.0000000000008735 URL
[23]	Ingala S, Mazzai L, Sudre CH, et al. The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals[J]. Neurobiol Aging, 2020, 95:104-114. doi: 10.1016/j.neurobiolaging.2020.06.015 URL
[24]	Zhu Z, Jiang Y, Cui M, et al. ALDH2 rs671 polymorphisms and the risk of cerebral microbleeds in Chinese elderly: The Taizhou imaging study[J]. Ann Transl Med, 2020, 8(5):229. doi: 10.21037/atm URL
[25]	Kim SH, Shin DW, Yun JM, et al. Kidney dysfunction and cerebral microbleeds in neurologically healthy adults[J]. PLoS One, 2017, 12(2):e0172210.
[26]	Peng Q, Sun W, Liu W, et al. Longitudinal relationship between chronic kidney disease and distribution of cerebral microbleeds in patients with ischemic stroke[J]. J Neurol Sci, 2016, 362:1-6. doi: 10.1016/j.jns.2016.01.015 URL
[27]	Lau WL, Nunes ACF, Vasilevko V, et al. Chronic kidney disease increases cerebral microbleeds in mouse and man[J]. Transl Stroke Res, 2020, 11(1):122-134 doi: 10.1007/s12975-019-00698-8 URL
[28]	Phillips NS, Hillenbrand CM, Mitrea BG, et al. Cerebral microbleeds in adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation[J]. Sci Rep, 2020, 10(1):692. doi: 10.1038/s41598-020-57682-8 URL
[29]	Greenberg SM, Charidimou A. Diagnosis of cerebral amyloid angiopathy: Evolution of the Boston criteria[J]. Stroke, 2018, 49:491-497. doi: 10.1161/STROKEAHA.117.016990 pmid: 29335334
[30]	Romero JR, Demissie S, Beiser A, et al. Relation of plasma β-amyloid, clusterin, and tau with cerebral microbleeds: Framingham heart study[J]. Ann Clin Transl Neurol, 2020, 7(7):1083-1091. doi: 10.1002/acn3.v7.7 URL
[31]	Van Veluw SJ, Frosch MP, Scherlek AA, et al. In vivo characterization of spontaneous microhemorrhage formation in mice with cerebral amyloid angiopathy[J]. J Cereb Blood Flow Metab, 2020, 27:271678X19899377.
[32]	Seaton A, Tran L, Chen R, et al. Pollution, particles, and dementia: A hypothetical causative pathway[J]. Int J Environ Res Public Health, 2020, 17(3):862. doi: 10.3390/ijerph17030862 URL

脑微出血机制与危险因素的研究进展

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 32

相关文章 15

编辑推荐

Metrics

本文评价

[1]	金鑫, 吴金玲, 尹丽丽. 持续性植物状态促醒机制及治疗研究进展[J]. 临床荟萃, 2024, 39(2): 172-176.
[2]	王琦, 陈宏. 维生素D在支气管哮喘和慢性阻塞性肺疾病治疗中的应用进展[J]. 临床荟萃, 2024, 39(1): 88-91.
[3]	余泽宇, 林希, 陈章华, 杨巍, 陈志敏, 张海. 儿童难治性肺炎支原体肺炎危险因素分析[J]. 临床荟萃, 2024, 39(1): 43-46.
[4]	刘丽丽, 袁宇婷, 赖耿良, 田川, 蓝翔, 叶中绿. 儿童急性淋巴细胞白血病第15天微小残留与预后的关系[J]. 临床荟萃, 2024, 39(1): 47-52.
[5]	位增, 曹灵, 佘敦敏, 刘彦, 王艳, 张真稳. 54例2型糖尿病患者合并新型冠状病毒感染的死亡原因分析[J]. 临床荟萃, 2023, 38(9): 806-812.
[6]	张娜文, 黄少敏, 田利民. 2型糖尿病与帕金森病相关性研究的进展[J]. 临床荟萃, 2023, 38(9): 845-850.
[7]	左腾, 王俊祥. 血清阴性类风湿关节炎发病机制的研究进展[J]. 临床荟萃, 2023, 38(8): 753-756.
[8]	武锐锋, 刘宇宏. PDZ结合激酶/T淋巴细胞因子激活的杀伤细胞源性蛋白激酶的作用机制及其在肿瘤治疗中的潜在价值[J]. 临床荟萃, 2023, 38(8): 763-768.
[9]	贾丽娜, 吴美妮, 尹昌浩. 2型糖尿病认知功能障碍发病机制的研究进展[J]. 临床荟萃, 2023, 38(6): 554-558.
[10]	王英南, 赵琦, 白海威, 武丹娜, 魏金梅, 李省江, 李锐凌, 张瑞星. 胃癌合并脑梗死的临床特点及危险因素分析[J]. 临床荟萃, 2023, 38(5): 417-422.
[11]	高玉叶, 徐海, 孙妍. 肥胖对呼吸功能的影响及机制[J]. 临床荟萃, 2023, 38(4): 381-384.
[12]	马明福, 魏志国, 何铁英. 急性胰腺炎并发胰腺假性囊肿危险因素的meta分析[J]. 临床荟萃, 2023, 38(4): 293-301.
[13]	冷婉铜, 陶洁. 多发性骨髓瘤患者治疗后发生静脉血栓栓塞的危险因素[J]. 临床荟萃, 2023, 38(4): 340-345.
[14]	王凤华, 魏茂提. 干式桑拿疗法治疗慢性心力衰竭的研究进展[J]. 临床荟萃, 2023, 38(4): 369-372.
[15]	邹琳, 崔轶霞, 张娜娜, 陈思荣. 类风湿关节炎合并骨质疏松症发病机制和相关治疗药物对骨质疏松症影响的研究进展[J]. 临床荟萃, 2023, 38(3): 279-284.