慢性失眠障碍患者血清鸢尾素、锰超氧化物歧化酶水平与认知功能的关系

doi:10.3969/j.issn.1004-583X.2022.04.008

摘要/Abstract

摘要：

目的检测慢性失眠障碍患者血清鸢尾素、锰超氧化物歧化酶(manganese-containing superoxide dismutase,MnSOD)水平,并探讨两者与慢性失眠障碍患者认知功能的关系。方法选取2019年9月-2020年12月于黄河中心医院神经内科接受治疗的慢性失眠障碍患者179例,其中未出现认知功能障碍86例(A组),出现认知功能障碍93例(B组),回顾性分析两组临床资料。结果与A组相比,B组匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)量表评分较高,血清鸢尾素、MnSOD水平及蒙特利尔认知评估(Montreal cognitive assessment,MoCA)量表评分降低(均P<0.05)。慢性失眠障碍认知功能损害患者血清鸢尾素、MnSOD水平与MoCA评分均呈正相关(r=0.493、0.604,均P<0.05)。血清鸢尾素、MnSOD水平降低是慢性失眠障碍患者发生认知功能损害的独立危险因素(均P<0.05)。血清鸢尾素、MnSOD预测慢性失眠障碍患者认知功能损害的曲线下面积(area under the curve,AUC)分别为0.805、0.732,特异度分别为89.5%、58.1%,敏感度分别为61.3%、84.9%;两者联合预测的AUC为0.897,特异度为95.3%,敏感度为59.1%。结论慢性失眠障碍患者血清鸢尾素、MnSOD水平与认知功能相关,对评估认知功能损害具有一定意义。

关键词: 入睡和睡眠障碍, 认知, 超氧化物歧化酶, 鸢尾素

Abstract:

Objective To detect the levels of serum irisin and manganese-containing superoxide dismutase (MnSOD) of patients with chronic insomnia, and exploring the relationship between the two and cognitive function. Methods Totally 179 patients with chronic insomnia treated in the Department of Neurology of Yellow River Central Hospital from September 2019 to December 2020 were selected, including 86 patients without cognitive impairment (group A) and 93 patients with cognitive impairment (group B). The clinical data of the two groups were retrospectively analyzed. Results Compared with group A, group B exhibited increased pittsburgh sleep quality index (PSQI) score, decreased serum irisin, MnSOD and Montreal cognitive assessment (MoCA) scores (all P<0.05). The positive correlations between serum irisin, MnSOD levels and MoCA scores in chronic insomnia patients with cognitive impairment were found (r=0.493, 0.604, all P<0.05). The decreased levels of serum iris and MnSOD were independent risk factors for cognitive impairment in patients with chronic insomnia (all P<0.05). The areas under the curve (AUC) of serum irisin and MnSOD in predicting cognitive impairment in patients with chronic insomnia were 0.805 and 0.732, respectively, with specificity of 89.5% and 58.1%, and sensitivity of 61.3% and 84.9%, respectively; the AUC, specificity and sensitivity of the combined prediction were 0.897, 95.3% and 59.1%, respectively. Conclusion Serum irisin and MnSOD levels have certain significance for cognitive impairment assessment of patients with chronic insomnia, which are closely related to cognitive function.

Key words: sleep initiation and maintenance disorders, cognition, superoxide dismutase, irisin

中图分类号:

R741

翟夏音, 兰瑞. 慢性失眠障碍患者血清鸢尾素、锰超氧化物歧化酶水平与认知功能的关系[J]. 临床荟萃, 2022, 37(4): 329-333.

Zhai Xiayin, Lan Rui. Relationship between serum irisin, manganese-containing superoxide dismutase and cognitive function of patients with chronic insomnia[J]. Clinical Focus, 2022, 37(4): 329-333.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2022.04.008

https://huicui.hebmu.edu.cn/CN/Y2022/V37/I4/329

图/表 7

参考文献 18

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组别	例数	年龄 (岁)	性别 (男/女)	BMI (kg/m²)	病程 (年)	受教育年限 (年)	吸烟史 [例(%)]	饮酒史 [例(%)]	PSQI评分 (分)
A组	86	68.32±7.24	38/48	21.18±2.24	6.62±2.62	11.28±2.91	29(33.7)	31(36.0)	14.98±3.36
B组	93	69.48±7.53	39/54	20.97±2.16	6.71±2.31	11.43±3.14	37(39.8)	34(36.6)	23.46±5.24
t/χ²值		1.049	0.092	0.638	0.244	0.331	0.706	0.005	12.773
P值		0.296	0.761	0.524	0.807	0.741	0.401	0.943	0.000

组别	例数	年龄 (岁)	性别 (男/女)	BMI (kg/m²)	病程 (年)	受教育年限 (年)	吸烟史 [例(%)]	饮酒史 [例(%)]	PSQI评分 (分)
A组	86	68.32±7.24	38/48	21.18±2.24	6.62±2.62	11.28±2.91	29(33.7)	31(36.0)	14.98±3.36
B组	93	69.48±7.53	39/54	20.97±2.16	6.71±2.31	11.43±3.14	37(39.8)	34(36.6)	23.46±5.24
t/χ²值		1.049	0.092	0.638	0.244	0.331	0.706	0.005	12.773
P值		0.296	0.761	0.524	0.807	0.741	0.401	0.943	0.000

组别	例数	鸢尾素 (ng/L)	MnSOD (U/ml)	MoCA评分 (分)
A组	86	3.25±0.84	10.46±3.23	27.24±1.46
B组	93	2.09±0.56	7.16±2.13	18.45±3.42
t值		10.946	8.126	22.046
P值		0.000	0.000	0.000

组别	例数	鸢尾素 (ng/L)	MnSOD (U/ml)	MoCA评分 (分)
A组	86	3.25±0.84	10.46±3.23	27.24±1.46
B组	93	2.09±0.56	7.16±2.13	18.45±3.42
t值		10.946	8.126	22.046
P值		0.000	0.000	0.000

影响因素	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
影响因素	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
鸢尾素	0.772	0.297	6.764	0.009	2.165	1.210	3.875
MnSOD	0.749	0.336	4.964	0.026	2.114	1.094	4.084
PSQI评分	0.195	0.126	2.389	0.122	1.215	0.949	1.555
MoCA评分	0.124	0.114	1.183	0.277	1.132	0.905	1.415