关键词: 糖尿病,妊娠, 门冬胰岛素, 维生素D

Abstract:

Objective To evaluate the clinical efficacy of insulin aspart combined with vitamin D (VD) supplementation for patients with gestational diabetes mellitus(GDM).Methods The randomized controlled trials (RCTs) of insulin aspart and VD in treating GDM were collected by searching electronic databases including CNKI, Wanfang, PubMed, etc, and the retrieval time extended from the creation of database to July 1, 2020. Two researchers independently screened trials that met the inclusion criteria and extracted the data of randomized controlled trials meeting inclusion criteria; the quality of literatures was evaluated by referring to the criterion for Cochrane quality evaluation, and RevMan 5.3 software was used to conduct the meta analysis.Results Twelve literature and 1130 cases (563 cases in the experimental group and 567 cases in the control group) were finally included. Meta analysis results showed that insulin aspart combined with VD supplementation could significantly reduce the fasting plasma glucose, 2 h postprandial glucose, fasting insulin, insulin resistance index. Meta analysis results also suggested that insulin aspart combined with VD supplementation significantly reduced the incidence of neonatal hypoglycemia, cesarean section, premature delivery and giant children.Conclusion Insulin aspart combined with VD supplementation can improve blood glucose metabolism, decrease insulin resistance and reduce the occurrence of adverse perinatal outcomes in patients with GDM. However, more high-quality RCTs remain to be verified.

Key words: diabetes,gestational, insulin aspart, Vitamin D