miR-361在心血管疾病的研究进展

doi:10.3969/j.issn.1004-583X.2021.09.016

摘要/Abstract

摘要：

微小RNA(microRNA, miRNA)是一类内源性单链非编码RNA分子,长度约21~23个核苷酸,通过结合靶基因的3'非翻译区转录调控基因的表达,参与细胞增殖、分化、凋亡等生物学活动,对机体内不同组织细胞的生长、发育产生重要影响。随着近几年对miRNA-361的深入研究,发现miRNA-361在心血管方面具有重要作用,并影响疾病的发展及预后。本文通过总结miR-361在心血管疾病如动脉粥样硬化(AS)、急性心肌梗死(AMI)、血管瘤(HA)、肺动脉高压(PAH)、静脉血栓栓塞症(VTE)、盐敏感高血压(SSH)等的表现,对近几年miR-361的相关机制与最新进展进行综述,期望未来能在miR-361方面为心血管疾病的预防、诊断和治疗带来新的启发。

关键词: 心血管疾病, 3'非翻译区, 细胞增殖, 细胞凋亡, 高血压, 肺性

中图分类号:

R541

叶蒙蒙, 李旎, 徐国栋, 邵国丰. miR-361在心血管疾病的研究进展[J]. 临床荟萃, 2021, 36(9): 843-849.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.09.016

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I9/843

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参考文献 64

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疾病类型	相关通路	ceRNA	靶基因	生物学功能
AS	APJ/PKCa JAK2/STAT3	MALAT1 MEG3	LPL Sirt1 SOCS3 SH2B1 ABCA1	参与糖、脂质代谢、细胞增殖转移,抑制炎症因子
AMI	未知	MEG3	PHB1 VEGF BCL2/BAX p53	参与血管生成、细胞增殖转移、抑制凋亡,影响线粒体功能
HA HHT CCM	TGFβ/BMP	NEAT1	VEGFA IGF1 RAC1 CCM2	参与血管生成、细胞增殖转移、细胞外基质降解
PAH	JAK/STAT3	未知	SERT VEGF ABCA1	参与血管重塑、脂质代谢、细胞增殖转移
VTE	TGFβ1/2	未知	FGF1	参与血管生成、细胞增殖转移
SSH	未知	OTX1-7:1	PRKCA	参与钙信号、血管平滑肌收缩、钠重吸收,调控钠离子转运体

疾病类型	相关通路	ceRNA	靶基因	生物学功能
AS	APJ/PKCa JAK2/STAT3	MALAT1 MEG3	LPL Sirt1 SOCS3 SH2B1 ABCA1	参与糖、脂质代谢、细胞增殖转移,抑制炎症因子
AMI	未知	MEG3	PHB1 VEGF BCL2/BAX p53	参与血管生成、细胞增殖转移、抑制凋亡,影响线粒体功能
HA HHT CCM	TGFβ/BMP	NEAT1	VEGFA IGF1 RAC1 CCM2	参与血管生成、细胞增殖转移、细胞外基质降解
PAH	JAK/STAT3	未知	SERT VEGF ABCA1	参与血管重塑、脂质代谢、细胞增殖转移
VTE	TGFβ1/2	未知	FGF1	参与血管生成、细胞增殖转移
SSH	未知	OTX1-7:1	PRKCA	参与钙信号、血管平滑肌收缩、钠重吸收,调控钠离子转运体

miR-361在心血管疾病的研究进展

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