阿戈美拉汀结合扑克牌类娱疗对首发重度抑郁症患者认知功能的影响

doi:10.3969/j.issn.1004-583X.2024.02.006

摘要/Abstract

摘要：

目的观察阿戈美拉汀结合扑克牌类娱疗对首发重度抑郁症患者认知功能损害的改善情况。方法选取2019年6月至2022年5月烟台市莱州荣军医院精神科收治的首次发作的重度抑郁发作患者122例,按随机数字表法将患者分为观察组(n=61)和对照组(n=61)。对照组单用阿戈美拉汀片治疗,观察组在阿戈美拉汀片药物治疗方案上结合扑克牌类娱疗。治疗8周后比较两组疗效。结果对照组因中断治疗脱落1例,实际完成60例;观察组因中断治疗脱落2例,实际完成59例。治疗前两组一般资料(性别、年龄、受教育年限、婚姻状况等)、汉密尔顿17项抑郁量表评分、蒙特利尔认知评估量表评分差异均无统计学意义(P>0.05)。治疗8周后,两组汉密尔顿17项抑郁量表评分差异无统计学意义(P>0.05);与对照组相比,观察组蒙特利尔认知评估量表评分较高,治疗前后MoCA评分差值较大,复燃率较低,差异有统计学意义(P<0.05)。结论阿戈美拉汀结合扑克牌类娱疗可更大程度改善首发重度抑郁症患者的认知功能,减少复燃。

关键词: 首发重度抑郁症, 认知, 阿戈美拉汀, 扑克牌类娱疗

Abstract:

Objective To observe the improvement effect of agomelatine combined with poker-based entertainment therapy on cognitive impairment in patients with first-episode major depressive disorder. Methods A total of 122 patients with first-episode major depressive disorder admitted to the Psychiatric Department of Laizhou Rongjun Hospital of Yantai City from June 2019 to May 2022 were enrolled. The patients were assigned into an observation group (n=61) and a control group (n=61) by a random number table method. The control group was treated with agomelatine alone, while patients in the observation group were additionally treated with agomelatine combined with poker-based entertainment therapy. The therapeutic effects of the two groups after 8 weeks of treatment were assessed. Results Attributable to treatment interruption, the actual number of patients completed in the control group and the observation group was 60 (1 shedding) and 59 (2 shedding), respectively. There was no statistically significant difference in general information (gender, age, years of education, marital status, etc.), 17-item Hamilton Rating Scale for Depression (HAMD-17) score, and Montreal Cognitive Assessment (MoCA) between groups before treatment (P>0.05). After 8 weeks of treatment, there was no statistically significant difference in HAMD-17 score between groups (P>0.05), but significantly elevated MoCA score and decreased relapse rate were detected in the observation group relative to the control group (P<0.05). Conclusion Agomelatine combined with poker-based entertainment therapy can significantly improve cognitive function and reduce relapse in patients with first-episode major depressive disorder.

Key words: first-episode major depressive disorder, cognition, agomelatine, poker-based entertainment therapy

中图分类号:

R749.4

原风英, 马晓玲, 曲军民. 阿戈美拉汀结合扑克牌类娱疗对首发重度抑郁症患者认知功能的影响[J]. 临床荟萃, 2024, 39(2): 130-133.

Yuan Fengying, Ma Xiaoling, Qu Junmin. Effect of agomelatine combined with poker-based entertainment therapy on cognitive function in patients with first-episode major depressive disorder[J]. Clinical Focus, 2024, 39(2): 130-133.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2024.02.006

https://huicui.hebmu.edu.cn/CN/Y2024/V39/I2/130

图/表 4

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组别	例数	性别 [女,例(%)]	年龄 (岁)	受教育年限 (年)	婚姻状况[例(%)]
组别	例数	性别 [女,例(%)]	年龄 (岁)	受教育年限 (年)	未婚	已婚/再婚	离异/丧偶
对照组	60	29(48.3)	41.29±11.55	12.51±4.89	5(8.3)	48(80.0)	7(11.7)
观察组	59	32(54.2)	39.04±10.85	11.22±4.05	5(8.5)	44(74.6)	10(17.0)
统计值		χ²=0.415	t=1.095	t=1.566		χ²=0.695
P值		0.519	0.276	0.120		0.707

组别	例数	性别 [女,例(%)]	年龄 (岁)	受教育年限 (年)	婚姻状况[例(%)]
组别	例数	性别 [女,例(%)]	年龄 (岁)	受教育年限 (年)	未婚	已婚/再婚	离异/丧偶
对照组	60	29(48.3)	41.29±11.55	12.51±4.89	5(8.3)	48(80.0)	7(11.7)
观察组	59	32(54.2)	39.04±10.85	11.22±4.05	5(8.5)	44(74.6)	10(17.0)
统计值		χ²=0.415	t=1.095	t=1.566		χ²=0.695
P值		0.519	0.276	0.120		0.707

组别	例数	治疗前	治疗8周后
对照组	60	34.85±6.03	8.57±4.29^#
观察组	59	36.08±7.81	8.33±5.61^#
t值		0.963	0.262
P值		>0.05	>0.05

组别	例数	治疗前	治疗8周后
对照组	60	34.85±6.03	8.57±4.29^#
观察组	59	36.08±7.81	8.33±5.61^#
t值		0.963	0.262
P值		>0.05	>0.05

组别	例数	治疗前	治疗8周后	治疗前后差值
对照组	60	20.50±3.91	23.74±5.38^*	3.35±0.88
观察组	59	20.59±4.40	26.28±5.77^*	4.17±1.28
t值		0.118	2.484	4.078
P值		0.906	0.014	0.000