临床荟萃 ›› 2022, Vol. 37 ›› Issue (5): 472-476.doi: 10.3969/j.issn.1004-583X.2022.05.017
俞杭1,2, 邬秀娣2(
)
收稿日期:2022-02-08
出版日期:2022-05-20
发布日期:2022-06-22
通讯作者:
邬秀娣
E-mail:wuxiudinbey@163.com
基金资助:
Received:2022-02-08
Online:2022-05-20
Published:2022-06-22
摘要：
强直性脊柱炎(ankylosing spondylitis,AS)是一种严重影响青壮年健康的慢性炎症性疾病,具体发病机制仍未明确。Keap1/Nrf2信号通路参与各种病理过程中的细胞保护机制,被认为是氧化应激的敏感传感器和调节器。临床发现AS患者血尿酸水平存在异常,目前认为尿酸可能通过Keap1/Nrf2通路参与调控AS氧化应激。本文总结了近年来AS与血尿酸水平及Keap1/Nrf2通路的研究进展,以期为深入了解AS的发病机制、监测病情和指导治疗提供新思路。
中图分类号:
俞杭, 邬秀娣. 尿酸作用于Keap1/Nrf2通路调控强直性脊柱炎氧化应激的研究进展[J]. 临床荟萃, 2022, 37(5): 472-476.
图1 尿酸作用于Keap1/Nrf2通路调控AS氧化应激的机制
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