骨质疏松与血尿酸相关性研究进展

doi:10.3969/j.issn.1004-583X.2021.10.017

摘要/Abstract

摘要：

骨质疏松症(osteoporosis,OP)以骨量低,骨组织微结构被破坏为特征,可导致骨脆性增加并易发生骨折。血尿酸(uric acid,UA)是人体嘌呤代谢的重要产物之一,正常水平下UA本身具有抗氧化性起到骨保护作用,但高水平的UA代谢产物反而可以诱导氧化应激,导致骨损伤。血UA也可以直接作用于多种骨代谢相关细胞,且在人体中受多种因素影响,包括维生素D及甲状旁腺激素(parathyroid hormone,PTH)等。近年来,国内外对OP与血清UA相关性的研究较多,但具体确切关系仍有所争议。本文探究血清UA水平与OP之间的关系,为临床治疗研究提供新的思路。

关键词: 骨质疏松, 成骨细胞, 破骨细胞, 尿酸

中图分类号:

R681

陈俏, 于晓华. 骨质疏松与血尿酸相关性研究进展[J]. 临床荟萃, 2021, 36(10): 951-955.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.10.017

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I10/951

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骨质疏松与血尿酸相关性研究进展

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