类风湿关节炎患者骨密度与维生素D相关性研究进展

doi:10.3969/j.issn.1004-583X.2024.01.018

摘要/Abstract

摘要：

类风湿关节炎(rheumatoid arthritis,RA)是一种慢性炎症性疾病,发生骨并发症时常伴有关节周围的骨丢失、骨侵蚀和全身性骨质疏松。RA患者关节畸形、活动障碍、糖皮质激素使用史都会增加骨质疏松症(osteoporosis,OP)的患病率和骨密度(bone mineral density,BMD)降低的风险。髋部和脊柱部的BMD测定对诊断OP具有重要意义。维生素 D的免疫活性形式1, 25-羟基维生素D₃对自身免疫性疾病具有免疫调节作用,尤其是RA。因此,探索RA患者BMD与维生素D的关系,可能对RA患者OP的早期评估和预防具有重要的指导意义。

关键词: 类风湿关节炎, 维生素D, 骨密度, 骨质疏松症

中图分类号:

R593.2

张娜娜, 崔轶霞, 邹琳. 类风湿关节炎患者骨密度与维生素D相关性研究进展[J]. 临床荟萃, 2024, 39(1): 92-96.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2024.01.018

https://huicui.hebmu.edu.cn/CN/Y2024/V39/I1/92

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