Abstract: ObjectiveThrough the analysis of type 2 diabetes mellitus(T2DM) patients with helicobacter pylori (Hp) infection status， to investigate the correlation between Hp and glucolipid metabolism in T2DM. MethodsThe study enrolled 195 cases of patients with T2DM who enderwent by gastroscope gastric mucosa biopsy or 13C urea breath test to determine Hp infection rate，and detections were performed in the common clinical indicators such as HbA1c，FBG，TG，TC，HDLC，LDLC， ALB， C peptide， insulin， 24hour urine protein，admission blood pressure， BMI and HOMRIR. ResultsHp infection rate  in diabetes group was 48.2%（94/195）， but that in control group  37.6%（88/234） (P＜0.05). In diabetic patients with Hp positive group，FBG，TG，ALB， 24 hours urinary protein， serum insulin， HOMR  IR were higher than in Hp negative group， serum cpeptide was lower than in Hp negative group (all P＜0.05).  ConclusionHp  infection rate in diabetic patients is higher， Hp infection may increase diabetes glucolipid metabolic disorders and insulin resistance. Eradicating Hp can improve the glucolipid metabolism in diabetic patients， reduce urinary protein， to a certain extent， can prevent and delay the occurrence  and development of diabetes complications.

Key words: diabetes mellitus, type 2, helicobacter pylori, lipid metabolism