Abstract: ObjectiveTo explore the influence of different therapies in children of HenochSchnlein purpura(HSP) with angioneurotic edema. MethodsRetrospectively study was performed on 1 012 cases with HSP， including onset  patterns， clinical manifestations and outcomes. According to HSP children with angioneurotic edema or not，the patients were divided into two groups: group A and B. With different therapies， group A subdivided into A1(treated with conventional therapy plus low molecular mass  heparin calcium) and A2(treated with conventional therapy plus dipyridamole). Comparison was made in the different sets of clinical indicators， laboratory indicators， and incidence rate of HSP nephritis (HSPN). ResultsOf 1 012 cases，402(39.7%)  patients had angioneurotic edema. The blood Ddimer level， the rash recurrence and HSPN incidence of group A were significantly lower than those of group B (P<0.05). After treatment， the angioneurotic edema in group A1 disappeared earlier than A2. The blood Ddimer level， the rash recurrence and HSPN incidence of group A1 were significantly lower than those of group A2 (P<0.05). ConclusionHSP patients with angioneurotic edema had a high incidence of HSPN because of the blood hypercoagulable state. And low molecular mass heparins calcium in early use can help relieve pain， reduce recurrence and have good prognosis.

Key words: purpura,HenochSchoelein; , angioedema, treatment, prognosis