Abstract: Objective To explore the clinical effects of advanced central lung cancer by chemotherapy combined with location intervened with electronic bronchoscopy.Methods Thirty-six cases of advanced central lung cancer patients were delt with standard first GP chemotherapy combined with location intervened by the electronic bronchoscopey.Treatment involved respectively argon plasma coagulation group(APC) then placed the bronchial support into bronchia. The another central group accepted simple anti-tumor drugs standard first GP treated. Both groups were evaluated for curative effect after two treatment cycles(21 days a cycle).Results The effective rate of combined group was 72.2% and the remission rate of symptoms was 69.4%. The one-year survival rate was 77.8%. The effective rate of the simple chemotherapy group was 28.6% and the remission rate of symptoms was 38.8%. The one-year survival rate was 44.9%.There were significant differences between two groups(P<0.01).Conclusion The efficacy of the chemotherapy combined with location intervened by the electronic bronchoscopy was significantly better than that of simple chemotherapy. It is a better way to treat advanced central lung cancer patients currently and it rapidly relieves the clinical symptoms.