Relationship analysis between subclinical hypothyroidism and atherosclerosis

doi:10.3969/j.issn.1004-583X.2016.04.010

Abstract

Abstract: Objective To explore the relationship between subclinical hypothyroidism (SCH) and atherosclerosis.Methods Eighty patients with SCH and eighty volunteers with euthyroidism were contained in the study as SCH group and control group, respectively. All indicators were examined as follows:thyroid function-related indicators such as TSH, FT3 and FT4; atherosclerosis-related indicator such as HDL-C,LDL-C,TC,TG,TXB2,CRP and cIMT. Correlation study was performed between indicators.Results The levels of TSH, LDL-C, TC and TXB2 in SCH group were significantly higher than those of control group(P<0.01). Pearson correlation analysis showed that TSH level was positively correlated with TC, LDL-C, TXB2 and cIMT level. Multivariate regression analysis showed that cIMT was independently correlated with LDL-C and TSH.Conclusion There appeared some correlation bteween the high level of TSH in patients with SCH and the development of atherosclerosis

Key words: hypothyroidism, thyrotropin, atherosclerosis

CLC Number:

R581.2

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Guo Ni, Gan Zhenzhao, Su Jianqing. Relationship analysis between subclinical hypothyroidism and atherosclerosis[J]. Clinical Focus, 2016, 31(4): 386-388.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.04.010

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I4/386

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[1]	Xu Yang, Xue Ling. Influencing factors for mild cognitive impairment in type H hypertension patients combined with type 2 diabetes mellitus [J]. Clinical Focus, 2023, 38(10): 887-892.
[2]	Chi Xiue, Zhang Qian, Li Wendong, Wang Yuansong, Kang Jingrui. Pseudohypoparathyroidism type Ia misdiagnosed as epilepsy: A case report and literatures review [J]. Clinical Focus, 2022, 37(9): 827-830.
[3]	Zhang Lei, Lou Haidong, Zhi Yu, Qi Shuying. Efficacy and safety of PCSK9 inhibitors on atherosclerotic cardiovascular disease: A meta-analysis [J]. Clinical Focus, 2022, 37(12): 1074-1080.
[4]	Zuo Xiuxiu, Hou Tianhua, Wang Hongxiang. Effect of subclinical hypothyroidism on prognosis of patients with chronic systolic heart failure: A meta-analysis [J]. Clinical Focus, 2022, 37(10): 905-911.
[5]	Cai Kexin, Guo Hongju, Yu Shuxia, Chang Lirong. Effect of levothyroxine for pregnancy outcomes due to subclinical hypothyroidism during pregnancy: A meta-analysis [J]. Clinical Focus, 2021, 36(9): 773-777.
[6]	Chen Jun, Zhou Yiwei, Li Xiujuan. Analysis of antithrombotic therapy for symptomatic lower extremity atherosclerosis disease [J]. Clinical Focus, 2021, 36(10): 937-941.
[7]	Shang Qihang, Chen Huaqian. Relationship between eosinophil levels and carotid atherosclerosis in maintenance hemodialysis patients [J]. Clinical Focus, 2021, 36(1): 44-48.
[8]	Zhang Yiran. A systematic review of hypoparathyroid cardiomyopathy [J]. Clinical Focus, 2020, 35(9): 783-787.
[9]	Wang Hongmei, Zhang Ting, Chen Jingjiong, Deng Jiangshan, Xu Zhouwei, Fu Jianliang, Zhao Yuwu. Association of lowlevel triiodothyronine with shortterm prognosis in patients with large artery atherosclerosis cerebral infarction [J]. Clinical Focus, 2020, 35(6): 517-520.
[10]	Yan Wen, Sun Bo, Ren Jiangong. Metaanalysis of the relationship between carotid atherosclerotic plaque and serum YKL 40 level in atherosclerotic cerebral infarction patients [J]. Clinical Focus, 2018, 33(8): 700-704.
[11]	Du Jianping1，An Zhenmei2a，Tang Xiangdong2b. Influence of obstructive sleep apnea hypopnea syndrome on thyroid function [J]. Clinical Focus, 2018, 33(2): 136-139.
[12]	Zhang Wei1，2， Zhang Mei1， Wang Yucheng1， Cui Dai1， Zhou Hongwen1，. Pseudohypoparathyroidism and hypokalemia: clinical manifestation analysis [J]. Clinical Focus, 2017, 32(9): 759-762.
[13]	Guo Yunfei1， Lu Qingyu1， Han Ping1， Zhang Ling1， Xu Dongmei1， Yang Jingwen1， Zhang Fuchun2. Antiatherosclerosis effect of sitagliptin in patients with type 2 diabetes mellitus [J]. Clinical Focus, 2016, 31(9): 975-977,982.
[14]	Hu Renming. Concept and clinical significance of metabolic inflammatory syndrome [J]. Clinical Focus, 2016, 31(9): 960-963.
[15]	Chen Lin1，2， Liu Jun2， Zhuang Chanjuan1， Li Guimei1， Deng Dongmei1. Levothyroxine replacement dose in patients with hypothyroidism during pregnancy [J]. Clinical Focus, 2016, 31(6): 669-672.