Abstract: Objective To explore the association between the 3'UTR +3908 C>T polymorphism of CNOT6 and susceptibility to gastric cancer in Han population. Methods The casecontrol study consisted of 960 patients with histopathologically verified primary gastric adenocarcinoma and age  and sexmatched healthy 972 controls in Chinese Han. The genotypes were determined by polymerase chain reactionbased restriction fragment length polymorphism (PCRRFLP). The associations between genotype and risk of developing gastric cancer were estimated by calculating the odds ratio (OR) and the 95% confidence interval (95% CI) with logistic regression models. Results For rs10069， subjects with TT/CT genotype had a decreased risk for developing gastric cancer  compared with CC genotype(OR=0.74; 95%CI=0.600.93). The association was more pronounced among individuals with <56 years of age. Moreover， a multiplicative joint effect between the CNOT6 SNP and Helicobacter pylori infection that intensified the risk was observed (OR for the presence of both CC genotype and H. pylori infection=2.32; 95%CI=1.413.82). No significant association was observed between the polymorphism and stage and grade of the cancer. Conclusion The +3908 C>T polymorphism of CNOT6 is associated with susceptibility to gastric cancer.

Key words: stomach neoplasms, polymorphism, single nucleotide, helicobacter pylori