Mitochondrial mutation m.3243A> G associated with diabetes mellitus: One case report and literature review

doi:10.3969/j.issn.1004-583X.2024.02.012

Abstract

Abstract:

Objective To investigate the screening and treatment of mitochondrial diabetes mellitus (MDM). Methods In this retrospective analysis, the clinical data and treatment process of one patient with m.3243A>G mutation-related MDM were analyzed, and relevant literature was reviewed. Results The 42-year-old female patient was admitted to the hospital due to poor blood glucose control and limb numbness. Combined with testing for mitochondrial gene, the patient received insulin combined with empagliflozin. Blood glucose control was improved and insulin dosage was reduced. Conclusion MDM has insulin resistance.Insulin combined with with SGLT-2 inhibitors can be treated, and its potential benefits need more comprehensive research.

Key words: mitochondrial, diabetes mellitus, insulin resistance, gene mutation

CLC Number:

R587.1

Lv Shasha, Song Jinlan, Shi Jian. Mitochondrial mutation m.3243A> G associated with diabetes mellitus: One case report and literature review[J]. Clinical Focus, 2024, 39(2): 160-163.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.02.012

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I2/160

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References 22

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项目	时间(h)
项目	0	0.5	1	2	3
血糖(mmol/L)	9.2	15.4	19.1	19.7	19.3
C肽(ng/ml)	0.62	0.97	1.18	1.86	2.10
胰岛素(μIU/ml)	26.41	30.91	32.79	33.59	34.78

项目	时间(h)
项目	0	0.5	1	2	3
血糖(mmol/L)	9.2	15.4	19.1	19.7	19.3
C肽(ng/ml)	0.62	0.97	1.18	1.86	2.10
胰岛素(μIU/ml)	26.41	30.91	32.79	33.59	34.78