Abstract: Objective  To investigate the influencing factors of prognosis in patients with acute organophosphorus pesticide poisoning. Methods  A retrospective analysis was carried out on 116 patients with acute organophosphorus pesticide poisoning  treated with blood purification from January 2006 to December 2014 in our hospital. The patients were divided into death group(n=35) and survival group(n=81) according to the treatment effect. The clinical and experimental results were compared,  and multivariate analysis was performed to establish a regression model. The ROC curve was used to analyze the prognostic value of the model. Results  The patients of death group were older,  had more basic diseases,  lower education level,  higher probability of applying combined blood purification,  higher APACHE Ⅱ score,  shorter hospital stay,  compared with the survival group (P<0.05). Multivariate analysis showed that APACHE Ⅱ score and hospital stay time were independent risk factors for the prognosis of acute organophosphorus pesticide poisoning (P<0.05). The model AUC area was 0.995,   the sensitivity was 0.911,  and the specificity was 0.962. Conclusion  APACHE Ⅱ score and hospital stay can be used to evaluate the prognosis of acute organophosphorus pesticide poisoning.

Key words: organophosphorus compounds, pesticide poisoning, prognosis