Predictive value of combined detection of RDW, NLR and D-dimer for acute pancreatitis

doi:10.3969/j.issn.1004-583X.2021.06.004

Abstract

Abstract:

Objective To investigate the predictive value of combined detection of red blood cell distribution width(RDW), neutrophil-lymphocyte ratio(NLR) and D-dimer for acute pancreatitis(AP). Methods Totally 210 AP patients diagnosed by department of gastroenterology were divided into mild group (n=126), moderate severe group (n=42), severe group (n=22), and critical group (n=20). The basic data and related parameters in four groups were compared to evaluate the predictive value of RDW, NLR, D-dimer and combined detection for the condition of AP. Results Comparison with basic data in four groups,the ruslt showed that RDW, NLR, D-dimer and white blood cells(WBC) levels were gradually increased from MAP group to CAP group, while serum calcium and albumin(ALB) levels were gradually decreased(P<0.05). The independent risk factors for the severity of AP were RDW and D-dimer. RDW+NLR+D-dimer showed sensitivity and specificity 60.8% and 87.5%, respectively. Conclusion RDW, NLR and D-dimer could all assess the severity of AP, of which RDW has better predictive value, and the combined of the three is more reliable to predict the severity of AP.

Key words: pancreatitis, erythrocytes, abnormal, neutropenia, D-dimer

CLC Number:

R576.1

Wu Hao, Li Jing. Predictive value of combined detection of RDW, NLR and D-dimer for acute pancreatitis[J]. Clinical Focus, 2021, 36(6): 504-508.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.06.004

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I6/504

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References 19

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组别	例数	性别(例)		年龄(岁)	病因[例(%)]
组别	例数	男	女	年龄(岁)	胆源性	高脂血症性	酒精性	其他
MAP	126	85	61	52.58±17.26	81(64.3)	14(11.1)	7(5.6)	24(19.0)
MSAP	42	24	18	53.45±19.80	23(54.8)	6(14.3)	4(9.5)	9(21.4)
SAP	22	4	8	63.58±19.28	14(63.6)	3(13.6)	3(13.6)	2(9.1)
CAP	20	6	4	45.80±12.64	13(65.0)	3(15.0)	2(10.0)	2(10.0)
统计值		χ²=0.600		F=2.009	χ²=7.112
P值		0.896		0.114	1.000

组别	例数	性别(例)		年龄(岁)	病因[例(%)]
组别	例数	男	女	年龄(岁)	胆源性	高脂血症性	酒精性	其他
MAP	126	85	61	52.58±17.26	81(64.3)	14(11.1)	7(5.6)	24(19.0)
MSAP	42	24	18	53.45±19.80	23(54.8)	6(14.3)	4(9.5)	9(21.4)
SAP	22	4	8	63.58±19.28	14(63.6)	3(13.6)	3(13.6)	2(9.1)
CAP	20	6	4	45.80±12.64	13(65.0)	3(15.0)	2(10.0)	2(10.0)
统计值		χ²=0.600		F=2.009	χ²=7.112
P值		0.896		0.114	1.000

组别		例数		Glu(mmol/L)^a		BUN(mmol/L)^a		Cr(μmol/L)^a		AMS(U/L)^a
MAP		126		7.65(6.10,10.83)		5.20(4.00,6.80)		64.70(52.45,78.80)		346.50(81.25,861.00)
MSAP		42		8.90(7.20,11.90)^*		5.00(3.80,6.20)^*		66.30(56.00,83.40)^*		558.00(166.00,1300.00)^*
SAP		22		8.90(7.60,13.30)		5.90(3.55,7.05)		74.50(52.45,96.10)		480.00(275.00,1300.00)
CAP		20		11.05(8.23,16.13)		7.05(4.83,8.95)		84.30(51.28,171.75)		395.50(217.25,635.25)
H值				9.338		5.177		4.043		6.863
P值				0.055		0.159		0.257		0.076
组别	例数		NLR^a		MPV(fl)^a		ALT(U/L)^a		AST(U/L)^a		D-D(mg/L)^a
MAP	126		6.43(3.53,11.07)		9.90(8.88,10.60)		23.00(15.00,57.00)		20.50(16.00,57.00)		0.46(0.34,0.77)
MSAP	42		8.82(5.93,20.46)^*		10.01(9.10,11.00)^*		26.00(16.00,119.00)^*		30.00(20.00,70.00)^*		0.64(0.42,1.29)^*
SAP	22		15.18(6.30,25.33)		9.50(8.40,10.60)		16.00(13.00,47.50)		22.00(17.00,51.50)		0.75(0.58,1.95)
CAP	20		16.97(8.92,26.17)		10.25(9.23,11.53)		20.00(12.75,41.00)		37.50(18.25,51.00)		0.81(0.63,2.73)
H值			22.860		3.844		4.739		5.350		14.065
P值			0.000		0.274		0.192		0.148		0.003
组别		例数		RDW(fl)^b		血钙(mmol/L)^b		WBC(×10⁹)^b		ALB(g/L)^b
MAP		126		40.81±2.53		2.26±0.17		11.10±3.68		39.38±3.72
MSAP		42		42.82±1.86^*		2.23±0.20^*		11.89±3.69^*		37.81±5.14^*
SAP		22		44.65±3.82		2.06±0.25		13.61±4.41		37.09±3.36
CAP		20		46.43±4.30		1.82±0.60		14.49±6.56		33.92±8.20
F值				29.732		18.169		4.852		8.058
P值				0.000		0.000		0.003		0.000

组别		例数		Glu(mmol/L)^a		BUN(mmol/L)^a		Cr(μmol/L)^a		AMS(U/L)^a
MAP		126		7.65(6.10,10.83)		5.20(4.00,6.80)		64.70(52.45,78.80)		346.50(81.25,861.00)
MSAP		42		8.90(7.20,11.90)^*		5.00(3.80,6.20)^*		66.30(56.00,83.40)^*		558.00(166.00,1300.00)^*
SAP		22		8.90(7.60,13.30)		5.90(3.55,7.05)		74.50(52.45,96.10)		480.00(275.00,1300.00)
CAP		20		11.05(8.23,16.13)		7.05(4.83,8.95)		84.30(51.28,171.75)		395.50(217.25,635.25)
H值				9.338		5.177		4.043		6.863
P值				0.055		0.159		0.257		0.076
组别	例数		NLR^a		MPV(fl)^a		ALT(U/L)^a		AST(U/L)^a		D-D(mg/L)^a
MAP	126		6.43(3.53,11.07)		9.90(8.88,10.60)		23.00(15.00,57.00)		20.50(16.00,57.00)		0.46(0.34,0.77)
MSAP	42		8.82(5.93,20.46)^*		10.01(9.10,11.00)^*		26.00(16.00,119.00)^*		30.00(20.00,70.00)^*		0.64(0.42,1.29)^*
SAP	22		15.18(6.30,25.33)		9.50(8.40,10.60)		16.00(13.00,47.50)		22.00(17.00,51.50)		0.75(0.58,1.95)
CAP	20		16.97(8.92,26.17)		10.25(9.23,11.53)		20.00(12.75,41.00)		37.50(18.25,51.00)		0.81(0.63,2.73)
H值			22.860		3.844		4.739		5.350		14.065
P值			0.000		0.274		0.192		0.148		0.003
组别		例数		RDW(fl)^b		血钙(mmol/L)^b		WBC(×10⁹)^b		ALB(g/L)^b
MAP		126		40.81±2.53		2.26±0.17		11.10±3.68		39.38±3.72
MSAP		42		42.82±1.86^*		2.23±0.20^*		11.89±3.69^*		37.81±5.14^*
SAP		22		44.65±3.82		2.06±0.25		13.61±4.41		37.09±3.36
CAP		20		46.43±4.30		1.82±0.60		14.49±6.56		33.92±8.20
F值				29.732		18.169		4.852		8.058
P值				0.000		0.000		0.003		0.000

项目	回归系数	标准误	OR值	P值	95%CI
项目	回归系数	标准误	OR值	P值	下限	上限
RDW	0.786	0.284	7.640	0.006	0.229	1.343
NLR	0.054	0.035	2.360	0.124	-0.015	0.122
D-二聚体	0.756	0.322	5.523	0.019	0.125	1.386
Cr	0.003	0.003	1.043	0.307	-0.003	0.010
血钙	-2.362	0.767	9.484	0.002	-3.865	-0.859
WBC	0.202	0.046	19.093	0.000	0.111	0.293
ALB	-0.037	0.036	1.066	0.302	-0.107	0.033