Correlation between the expression level of SPARC and prognosis in patients with non-small cell lung cancer: A meta-analysis

doi:10.3969/j.issn.1004-583X.2023.11.002

Abstract

Abstract:

Objective Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin and basal membrane-40 (BM-40), is a small molecule glycoprotein related to cell secretion. It promotes the invasion and metastasis of a variety of malignant tumors, which is correlated with the poor prognosis of tumor patients. At present, the prognostic role of SPARC in non-small cell lung cancer (NSCLC) is still controversial. This meta-analysis aims to assess the expression level of SPARC in NSCLC patients and its correlation with the prognosis. Methods Articles reporting the expression level of SPARC in NSCLC patients with and its correlation with the prognosis were systematically searched in the PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang databases. Data analysis was performed using Review Manager 5.4 software. Hazard ratio ( $H R$ ) and 95% Confidence interval ( $C I$ ) were calculated to assess the expression level of SPARC and its correlation with the overall survival (OS) of NSCLC patients. Results A total of 5 studies involving 430 NSCLC patients were recruited. Heterogeneity was tested ( $I 2$ =31%, $P$ =0.21), and the $H R$ of the pooled data using a fixed effects model was 1.77(95% $C I$ : 1.41-2.21), indicating that the high level of SPARC was correlated with a poor OS in NSCLC patients. A subgroup analysis based on the methylation of SPARC was conducted. There was no heterogeneity ( $I 2$ =0%, $P$ =0.89) in the articles without reporting the methylation of SPARC, with the combined $H R$ of 1.97(95% $C I$ : 1.40-2.79). A significant heterogeneity was detected in the articles reporting the methylation of SPARC ( $I 2$ =80%, $P$ =0.03), with the combined $H R$ of 1.63(95% $C I$ : 1.21-2.19), indicating that the prognostic significance of SPARC was changed by the presence or absence of methylation. Conclusion High level of SPARC predicts a poor prognosis in NSCLC patients, which can be used as a potential biomarker to assess the prognosis of NSCLC.

Key words: carcinoma, non-small-cell lung, SPARC, overall survival, prognosis, meta-analysis

CLC Number:

R730.26

Zhang Na, Sun Yue, Dong Han, Zhao Peng, Yang Xin, Qi Yuan, Wang Lingling. Correlation between the expression level of SPARC and prognosis in patients with non-small cell lung cancer: A meta-analysis[J]. Clinical Focus, 2023, 38(11): 972-978.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2023.11.002

https://huicui.hebmu.edu.cn/EN/Y2023/V38/I11/972

Figures/Tables 6

Fig.1 Flow chart of literature screening

Tab.1 Basic characteristics of enrolled studies

第一作者	出版年份	国家	病例数	检测方法	随访时间	组织学类型	分级	生存时间		无病生存期
第一作者	出版年份	国家	病例数	检测方法	随访时间	组织学类型	分级	$H R$	95% $C I$	$H R$	95% $C I$
Fabrizio^[12]	2020	Italy	59	IHC	52	NSCLC	Ⅰ-Ⅲ	1.46	1.07-2.00	0.98	0.61-1.57
Kurtul^[13]	2014	Turkey	84	IHC	12.5	NSCLC	Ⅲ	1.97	1.20-3.21	1.67	1.05-2.66
Suzuki^[14]	2005	Japan	84	IHC	NA	NSCLC	Ⅰ-Ⅳ	4.65	1.75-12.35	NA	NA
Xu^[15]	2019	China	90	IHC	NA	SCC	Ⅰ-Ⅳ	2.26	1.11-4.59	NA	NA
Koukourakis^[16]	2003	Britain	113	IHC	55.9	NSCLC	Ⅰ-Ⅱ	1.77	0.91-3.44	NA	NA

Tab.1 Basic characteristics of enrolled studies

第一作者	出版年份	国家	病例数	检测方法	随访时间	组织学类型	分级	生存时间		无病生存期
第一作者	出版年份	国家	病例数	检测方法	随访时间	组织学类型	分级	$H R$	95% $C I$	$H R$	95% $C I$
Fabrizio^[12]	2020	Italy	59	IHC	52	NSCLC	Ⅰ-Ⅲ	1.46	1.07-2.00	0.98	0.61-1.57
Kurtul^[13]	2014	Turkey	84	IHC	12.5	NSCLC	Ⅲ	1.97	1.20-3.21	1.67	1.05-2.66
Suzuki^[14]	2005	Japan	84	IHC	NA	NSCLC	Ⅰ-Ⅳ	4.65	1.75-12.35	NA	NA
Xu^[15]	2019	China	90	IHC	NA	SCC	Ⅰ-Ⅳ	2.26	1.11-4.59	NA	NA
Koukourakis^[16]	2003	Britain	113	IHC	55.9	NSCLC	Ⅰ-Ⅱ	1.77	0.91-3.44	NA	NA

Fig. 2 Forest plot for the association between SPARC expression level and OS in NSCLC patients

Fig.3 Subgroup analysis

Fig. 4 Funnel plot of publication bias for OS

Fig. 5 Sensitivity analysis of the relationship between SPARC expression and OS

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