酒精使用障碍患者认知功能损害发病机制的研究进展

doi:10.3969/j.issn.1004-583X.2023.12.013

摘要/Abstract

摘要：

酒精是一种中枢神经系统抑制剂,长期大量饮酒对情绪、行为、注意力、记忆、言语和协调均有广泛的不良影响,先前的研究证实其与多种疾病的发生相关。酒精使用障碍(alcohol use disorder,AUD)是一种复发性脑病,是主要的全球健康问题之一,对个人和社会产生了全球性影响。既往有研究发现部分酒精使用障碍患者存在认知功能损害,主要表现为记忆、执行功能、视觉空间能力、语言等多方面的功能受损,其发病机制较为复杂,涉及多个方面,但目前国内外研究尚未完全阐明酒精导致认知损害的相关发病机制。本文旨在对神经营养因子水平降低、血脑屏障破坏、维生素缺乏等与AUD所致认知功能损害相关的发病机制作以下综述,期望为AUD患者认知损害的病因学研究、治疗及预防提供更多科学依据。

关键词: 酒精, 酒精相关性障碍, 认知功能损害, 发病机制

中图分类号:

R749.62

彭艳, 白碧玥, 朱晓峰, 尹昌浩. 酒精使用障碍患者认知功能损害发病机制的研究进展[J]. 临床荟萃, 2023, 38(12): 1131-1134.

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https://huicui.hebmu.edu.cn/CN/Y2023/V38/I12/1131

参考文献 39

[1]	Rehm J, Shield KD. Global Burden of Alcohol Use Disorders and Alcohol Liver Disease[J]. Biomedicines, 2019, 7(4):99. doi: 10.3390/biomedicines7040099 URL
[2]	World Health Organization. Global status report on alcohol and health2018[EB/OL]. 2018. https://www.who.int/publications/i/item/9789241565639.
[3]	Li YR, Wang J, Zhao LY, et al. The drinking status and associated factors in adults in China[J]. Zhonghua Liu Xing Bing Xue Za Zhi, 2018, 39(7): 898-903.
[4]	Mistarz N, Andersen K, Nielsen AS, et al. Pharmacological enhancing agents targeting cognition in patients with alcohol-induced neurocognitive disorders: A systematic review[J]. Neurosci Biobehav Rev, 2021, 125:608-626. doi: 10.1016/j.neubiorev.2021.02.038 pmid: 33667552
[5]	Le Berre AP. Emotional processing and social cognition in alcohol use disorder[J]. Neuropsychology, 2019, 33(6):808-821. doi: 10.1037/neu0000572 URL
[6]	Jacob A, Wang P. Alcohol intoxication and cognition: implications on mechanisms and therapeutic strategies[J]. Front Neurosci, 2020, 14:102. doi: 10.3389/fnins.2020.00102 URL
[7]	Topiwala A, Ebmeier KP. Effects of drinking on late-life brain and cognition[J]. Evid Based Ment Health, 2018, 21(1):12-15. doi: 10.1136/eb-2017-102820 URL
[8]	Lu B, Nagappan G, Lu Y. BDNF and synaptic plasticity, cognitive function, and dysfunction[J]. Handb Exp Pharmacol, 2014, 220:223-250. doi: 10.1007/978-3-642-45106-5_9 pmid: 24668475
[9]	Boschen KE, Klintsova AY. Neurotrophins in the brain: Interaction with alcohol exposure during development[J]. Vitam Horm, 2017, 104:197-242. doi: S0083-6729(16)30057-7 pmid: 28215296
[10]	Carito V, Ceccanti M, Ferraguti G, et al. NGF and BDNF alterations by prenatal alcohol exposure[J]. Curr Neuropharmacol, 2019, 17: 308-317. doi: 10.2174/1570159X15666170825101308 pmid: 28847297
[11]	Heberlein A, Büscher P, Schuster R, et al. Do changes in the BDNF promoter methylation indicate the risk of alcohol relapse?[J]. Eur Neuropsychopharmacol, 2015, 25(11):1892-1897. doi: 10.1016/j.euroneuro.2015.08.018 pmid: 26404404
[12]	Silva-Peña D, García-Marchena N, Alén F, et al. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats[J]. Addict Biol, 2019, 24(5):1019-1033. doi: 10.1111/adb.12668 pmid: 30277635
[13]	Sweeney MD, Sagare AP, Zlokovic BV. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders[J]. Nat Rev Neurol, 2018, 14(3):133-150. doi: 10.1038/nrneurol.2017.188 pmid: 29377008
[14]	Rubio-Araiz A, Porcu F, Pérez-Hernández M. et al. Disruption of blood-brain barrier integrity in postmortem alcoholic brain: Preclinical evidence of TLR4 involvement from a binge-like drinking model[J]. Addict Biol, 2017, 22(4):1103-1116. doi: 10.1111/adb.12376 pmid: 26949123
[15]	Wei J, Qin L, Fu Y, Dai Y, Wen Y, Xu S. Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier[J]. Drug Chem Toxicol, 2022, 45(1):231-238. doi: 10.1080/01480545.2019.1681444 URL
[16]	Tachibana M, Holm ML, Liu CC, et al. APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1[J]. J Clin Invest, 2019, 129(3):1272-1277. doi: 10.1172/JCI124853 pmid: 30741718
[17]	Zhao XS, Peng J, Wu Q, et al. Imbalanced cholesterol metabolism in Alzheimer's disease[J]. Clin Chim Acta, 2016, 456:107-114. doi: 10.1016/j.cca.2016.02.024 URL
[18]	Liu CC, Hu J, Zhao N, et al. Astrocytic LRP1 mediates Brain Aβ clearance and impacts amyloid deposition[J]. J Neurosci, 2017, 37(15):4023-4031. doi: 10.1523/JNEUROSCI.3442-16.2017 URL
[19]	Cai Z, Qiao PF, Wan CQ, et al. Role of blood-brain barrier in alzheimer’s disease[J]. Alzheim Dis, 2018, 63 (4): 1223-1234.
[20]	Sánchez-Campillo M, Ruiz-Pastor MJ, Gázquez A, et al. Decreased blood level of MFSD2a as a potential biomarker of Alzheimer's disease[J]. Int J Mol Sci, 2019, 21(1):70. doi: 10.3390/ijms21010070 URL
[21]	Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders[J]. Lancet Neurol, 2018, 17(11): 1016-1024. doi: S1474-4422(18)30318-1 pmid: 30353860
[22]	Mader S, Brimberg L. Aquaporin-4 water channel in the brain and its implication for health and disease[J]. Cells, 2019, 8(2):90. doi: 10.3390/cells8020090 URL
[23]	Spear LP. Effects of adolescent alcohol consumption on the brain and behaviour[J]. Nat Rev Neurosci, 2018, 19(4):197-214. doi: 10.1038/nrn.2018.10 pmid: 29467469
[24]	van de Haar HJ, Burgmans S, Jansen JF, et al. Blood-brain barrier leakage in patients with early alzheimer disease[J], Radiology, 2016, 281(2):527-535. pmid: 27243267
[25]	van de Haar HJ, Jansen JFA, Jeukens CRLPN, et al. Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI[J]. Med Phys, 2017, 44(8):4112-4125. doi: 10.1002/mp.12328 pmid: 28493613
[26]	Nation DA, Sweeney MD, Montagne A, et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction[J], Nat Med, 2019, 25(2):270-276. doi: 10.1038/s41591-018-0297-y pmid: 30643288
[27]	Wei J, Dai Y, Wen W, et al. Blood-brain barrier integrity is the primary target of alcohol abuse[J]. Chem Biol Interact, 2021, 337:109400. doi: 10.1016/j.cbi.2021.109400 URL
[28]	Fama R, Le Berre AP, Hardcastle C, et al. Neurological, nutritional and alcohol consumption factors underlie cognitive and motor deficits in chronic alcoholism[J]. Addict Biol, 2019, 24(2):290-302. doi: 10.1111/adb.12584 pmid: 29243370
[29]	孙艳红, 夏清荣, 庞良俊, 等. 酒精使用障碍患者认知功能损害的影响因素[J]. 神经损伤与功能重建, 2021, 16(5):283-286.
[30]	Ridley NJ, Draper B, Withall A. Alcohol-related dementia: An update of the evidence[J]. Alzheimers Res Ther, 2013, 5(1):3. doi: 10.1186/alzrt157 pmid: 23347747
[31]	Gong YS, Hu K, Yang LQ, et al. Comparative effects of EtOH consumption and thiamine deficiency on cognitive impairment, oxidative damage, and β-amyloid peptide overproduction in the brain[J]. Free Radic Biol Med, 2017, 108:163-173. doi: 10.1016/j.freeradbiomed.2017.03.019 URL
[32]	Yung YC. Stoddard NC.& Chun J. LPA receptor signaling: Pharmacology, physiology, and pathophysiology[J]. Lipid Res, 2014, 55 (7): 1192-1214.
[33]	García-Marchena N, Pizarro N, Pavón FJ, et al. Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients[J]. Sci Rep, 2020, 10(1):17163. doi: 10.1038/s41598-020-74155-0 pmid: 33051508
[34]	Zhang JB, Cong YN, Li ZG, et al. Plasma phospholipids are associated with mild cognitive impairment in type 2 diabetic patients[J]. Curr Alzheimer Res, 2017, 14(6): 592-597. doi: 10.2174/1567205013666161201200722 URL
[35]	Castilla-Ortega E, Hoyo-Becerra C, Pedraza C, et al. Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA₁ receptor knockout mice[J]. PLoS One, 2011, 6(9):e25522. doi: 10.1371/journal.pone.0025522 URL
[36]	Silva-Peña D, García-Marchena N, Alén F, et al. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats[J]. Addict Biol, 2019, 24(5):1019-1033. doi: 10.1111/adb.12668 pmid: 30277635
[37]	Silva-Peña D, Rivera P, Alén F, et al. Oleoylethanolamide modulates BDNF-ERK signaling and neurogenesis in the hippocampi of rats exposed to Δ9-THC and ethanol binge drinking during adolescence[J]. Front Mol Neurosci, 2019, 12:96. doi: 10.3389/fnmol.2019.00096 pmid: 31068789
[38]	杜静, 罗振国. 长期酗酒和酒精相关脑部损伤[J]. 脑与神经疾病杂志, 2023, 31(5):320-323.
[39]	Spindler C, Mallien L, Trautmann S, et al. A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder[J]. Transl Psychiatry, 2022, 12(1):40. doi: 10.1038/s41398-022-01809-0

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