Abstract: ObjectiveTo analyze pathogen distribution and antimicrobial resistance of  bacilli from cerebrospinal fluid among children with central nervous system infection. MethodsThe VITEK32 was used for bacteria identification.The bacterial susceptibility testing was done by KirbyBauer method. The antimicrobial susceptibility was determined according to CLSI standard. Results1990 cerebrospinal fluid of children with central nervous system infection were detected. 181 strains were isolated，and the detection rate was 9.1% （181/1990）．The isolated rate of bacteria was 95.0%（172/181）  and fungus rate was  5.0%（9/181）.The rate of Streptococcus pneumonia， Staphylococcus epidermidis and Escherichia coli were 19.3% （35/181），18.8%（34/181），17.1%（31/181），respectively. The isolated rate of ESBLs of Escherichia coli and Klebsiella pneumoniae were 41.9%（13/31）  and  50.0% (3/6). The isolated rate of  tripredominant bacteria were the highest in pediatric patients with one year of age. The drug of resistant rates of  fundamental gramnegative bacteria including Escherichia coli and Klebsiella pneumoniae to ertapenem and imipenem were 0. The resistance to vancomycin of grampositive bacteria was not detected. ConclusionIt is important to apply clinical antibiotics for increasing antibiotics susceptibility on the basis of cultivation results and antimicrobial resistance of bacilli from cerebrospinal fluid among children with central nervous system infection.

Key words: diabetes mellitus, lipids, meningitis, bacterial, drug resistance, bacterial；child