Abstract: Objective  To investigate clinical characteristics of lower extremity arterial disease in type 2 diabetic patients, and to further evaluate longterm effect and clinical significance of lower extremity arterial intervention. Methods  Totally 362 patients were followed up who underwent lower extremity arterial intervention in our department from 2007 to 2014 for 7 years. Furthermore, we analyzed their clinical characteristics. Totally 393 legs (stage IIb to Ⅳ in Fontaine′s classification) of 362 patients has underwent DSA examinations. The appropriate interventional therapeutic method was chosen based on the results from DSA examinations. Patients took routine treatments including antihyperglycemic, antihypertensive, anticoagulant and antiplatelet therapy. All patients followed guidance for dieting and exercise. Results  Altogether 362 patients (43 cases were out of followed), 74 cases died, mortality rate was 23.2%. Among death cases, 36 cases died of cardiovascular and cerebrovascular diseases, 6 cases died of diabetic nephropathy, 4 cases died of foot infection, 3 cases died of respiratory tract infection, 16 cases died of tumor, 9 cases died of uncertain cause. Among survived 245 cases, iliac artery disease in 19 cases (20 arteries), femoralpopliteal artery disease in 63 cases (69 arteries), belowtheknee artery disease in 124 cases (133 arteries), critical femoralpopliteal artery and belowtheknee artery disease in 39 cases (46 arteries). Restenosis in five years was found in 93 cases (94 arteries: including restenosis of bilateral belowtheknee artery in 1 case ), and 76 cases of them were post belowtheknee arterial intervention: 6 cases with amputation; 52 cases with second operation. The artificial vessel grafts were patent in 132 cases. The remained 20 cases were unable to estimate. Conclusion  The main target of lower extremity arterial intervention was belowtheknee arterial disease in type 2 diabetic patients. Lower extremity arterial intervention was a treatment with excellent Longterm efficiency, high success rate and high limb salvage rate. The medical and exercise treatment played a decisive role in maintenance of Longterm patency after a successful intervention.

Key words: diabetes mellitus, , type 2, Diabetic angiopathy, Interventional therapy, forward patency