Effects of pituitrin combined with epinephrine in cardiopulmonary resuscitation: A meta-analysis

doi:10.3969/j.issn.1004-583X.2024.03.002

Abstract

Abstract:

Objective To systematically evaluate the effects of pituitrin combined with epinephrine in treating cardiopulmonary resuscitation (CPR). Methods We retrieved the literatures about pituitrin combined with epinephrine in treating CPR published in PubMed, The Cochrane Library, VIP, China National Knowledge Infrastructure (CNKI) and WanFang Date from inception to October 2022. Literature selection, quality evaluation and data extraction were performed according to inclusion and exclusion criteria, and a meta-analysis was completed by RevMan 5.3. Results Seventeen eligible literatures representing 1059 patients were included. The results of meta-analysis showed that pituitrin combined with epinephrine significantly increased the rate of return of spontaneous circulation (ROSC) (RR=2.02, 95%CI[1.74, 2.34], P<0.01), shorten the time to ROSC (MD=-8.91, 95%CI[-11.13, -6.69], P<0.01), and significantly increased the 24 h survival rate (RR=2.43, 95%CI[1.86, 3.18], P<0.01) and discharge survival rate (RR=2.41, 95%CI[1.83, 3.18], P<0.01), significantly reduced termination-of-resuscitation rate (RR=0.39, 95%CI[0.22, 0.68], P=0.001), significantly increased urine volume at 6 hours after resuscitation (MD=130, 95%CI[113.68, 146.32], P<0.01). However, after resuscitation, there was no significant difference in mean arterial pressure and ST-segment depression on electrocardiography between groups. Conclusion Pituitrin combined with epinephrine on CPR can significantly improve the success rate of resuscitation, shorten the time to resuscitation, improve 24 h and discharge survival rate, increase urine volume at 6 hours after resuscitation, and improve organ perfusion.

Key words: cardiopulmonary resuscitation, pituitrin, epinephrine, Meta-analysis

CLC Number:

R654.1

Li Guanzhu, Yang Yating, Deng Jinhe, Shao Lan, Zeng Chaokun. Effects of pituitrin combined with epinephrine in cardiopulmonary resuscitation: A meta-analysis[J]. Clinical Focus, 2024, 39(3): 208-215.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.03.002

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I3/208

Figures/Tables 12

References 38

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纳入研究	样本量 (P/E)	年龄(岁) (P/E)	患者类型	干预措施(P/E)	结局指标
张楠2020^[8]	23/23	65.7±5.6 65.4±5.3	呼吸心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	④
刘喆2016 ^[9]	36/36	56.1±2.3 55.7±2.1	心肺复苏患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④⑥⑦⑧
刘喆2015^[10]	19/19	31.32±2.71	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③
邵宝德2015^[11]	50/50	48.7±13.4 50.2±10.3	呼吸心跳骤停患	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
刘建凌2014^[12]	25/25	64.27±5.36 64.65±5.39	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
吕鋆2013^[13]	22/18	60.2±19.4	心跳骤停患者	垂体后叶素24 U+肾上腺素1 mg/肾上腺素1 mg	①④
梁振佳2013^[14]	31/29	56±17	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②⑤
钟敏华2013^[15]	31/30	60.2±19.6	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④⑤
蒋勇2012^[16]	26/19	52.3±4.5	呼吸心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④⑥⑦⑧
浦清2012^[17]	45/45	50.5	呼吸心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③⑥
张丽2011^[18]	30/29	61.4±21.5	心跳骤停患者	垂体后叶素20 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
黄兆章2010^[19]	26/23	58.7±19.6	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①④
胡运杰2010^[20]	52/51	63.1	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①④⑤
刘坤2009^[21]	32/30	/	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
张红2009^[22]	26/30	64	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③
莫文庆2008^[23]	30/28	62.4±21.8	心跳骤停患者	垂体后叶素20 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
毕晓峰2005^[24]	37/31	62.4±20.2	心跳骤停患者	垂体后叶素20 U+肾上腺素1 mg/肾上腺素1 mg	①②

纳入研究	样本量 (P/E)	年龄(岁) (P/E)	患者类型	干预措施(P/E)	结局指标
张楠2020^[8]	23/23	65.7±5.6 65.4±5.3	呼吸心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	④
刘喆2016 ^[9]	36/36	56.1±2.3 55.7±2.1	心肺复苏患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④⑥⑦⑧
刘喆2015^[10]	19/19	31.32±2.71	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③
邵宝德2015^[11]	50/50	48.7±13.4 50.2±10.3	呼吸心跳骤停患	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
刘建凌2014^[12]	25/25	64.27±5.36 64.65±5.39	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
吕鋆2013^[13]	22/18	60.2±19.4	心跳骤停患者	垂体后叶素24 U+肾上腺素1 mg/肾上腺素1 mg	①④
梁振佳2013^[14]	31/29	56±17	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②⑤
钟敏华2013^[15]	31/30	60.2±19.6	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④⑤
蒋勇2012^[16]	26/19	52.3±4.5	呼吸心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④⑥⑦⑧
浦清2012^[17]	45/45	50.5	呼吸心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③⑥
张丽2011^[18]	30/29	61.4±21.5	心跳骤停患者	垂体后叶素20 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
黄兆章2010^[19]	26/23	58.7±19.6	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①④
胡运杰2010^[20]	52/51	63.1	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①④⑤
刘坤2009^[21]	32/30	/	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
张红2009^[22]	26/30	64	心跳骤停患者	垂体后叶素40 U+肾上腺素1 mg/肾上腺素1 mg	①②③
莫文庆2008^[23]	30/28	62.4±21.8	心跳骤停患者	垂体后叶素20 U+肾上腺素1 mg/肾上腺素1 mg	①②③④
毕晓峰2005^[24]	37/31	62.4±20.2	心跳骤停患者	垂体后叶素20 U+肾上腺素1 mg/肾上腺素1 mg	①②