Abstract: Objective To explore the diagnosis value of α-L-fucosidase (AFU),5'-nucleo tidase (5’-NT) and alpha fetoprotein (AFP) detection in patients with primary hepatic carcinoma(PHC).Methods The study involved 40 patients with hepatocellular carcinoma as experimental group and 60 cases of physical examination as control group, using ROC curve to make a comparative analysis. The patients with hepatocellular carcinoma who experienced surgical treatment were followed up for average six months.The patients were divided into relapse group and non-recurrent group, to AFU, 5 - NT, AFP levels were detected to assess the predictive value.Results The level of AFU,5’-NT and AFP in PHC group were higher than those in control group (P<0.05).The area under the ROC curve for the three indexes were 0.904, 0.870 and 0.866,respectively. The concentrations of AFU in preoperative and postoperative detection were significantly higher than those of non-recurrent group. However, 5 - NT concentration showed no statistic difference between preoperative and postoperative concentration detection. Preoperative concentration of AFP was no significantly higher than that of non-recurrent group, but preoperation concentration of AFP was significantly higher than that of non recurrent group.Conclusion ROC curve suggests that the combined detection of AFU and 5' –NT is superior to any single index in PHC diagnosis.It can greatly increase the detection of PHC. AFU could be used as early recurrence indicator of PHC.