Abstract: Objective  To investigate the effect of high flux hemodialysis(HFHD)  combined with Lcarnitine therapy on lipid metaolism in uremic patients.Methods  Seventytwo  uremic patients were randomly divided into three groups. Group hemodialysis（HD）was treated by lowflux hemodialysis three times a week. Group HFHD was treated by  HFHD three times a week. Group HFHD+Lcarnitine was treated by HFHD three times a week,  and the patients were given Lcarnitine injection treatment at the end of each HFHD.All patients were followed up for 3 months. TC，TG，HDL，LDL,  Hb,  Alb were measured before and after the 3 months’ treatments,  then the KT/V ratio and URR was calculated. Results   TG increased in group HD before and after treatment (P<0.05). Compared to HD group,  TG decreased and Hb increased significantly in group HFHD and HFHD+Lcarnitine before and after treatment (P<0.05). However,  TG decrease and Hb increase had no significant differences between HFHD and HFHD+Lcarnitine group (P>0.05). LDL reduction is more significant in group HFHD+Lcarnitine than in group HD and HFHD (P<0.05). Conclusion  HFHD  combined with Lcarnitine  might effectively improve lipid metabolism in MHD patients.

Key words: renal dialysis, hemopurification, Lcarnitine, uremia, lipid